Target Name: IKZF4
NCBI ID: G64375
Other Name(s): Zinc finger protein, subfamily 1A, 4 (Eos) | IKAROS family zinc finger 4 | Ikaros family zinc finger protein 4 | Zinc finger protein Eos | KIAA1782 | IKZF4 variant 1 | Zinc finger protein Eos (isoform a) | IKAROS family zinc finger 4, transcript variant 1 | IKZF4 variant 4 | zinc finger transcription factor Eos | zinc finger protein, subfamily 1A, 4 (Eos) | IKZF4 variant 2 | ZNFN1A4 | IKAROS family zinc finger 4, transcript variant 2 | IKZF4_HUMAN | Zinc finger protein Eos isoform a | Zinc finger transcription factor Eos | EOS | Zinc finger protein Eos isoform c | IKAROS family zinc finger 4, transcript variant 4 | ikaros family zinc finger protein 4

Unlocking the Potential of IKZF4: A Zinc Finger Protein in the Context of Drug Targeting and Biomarker Development

Introduction

The zinc finger protein (IKZF4) is a member of the subfamily 1A of the Zinc Finger gene family, which has been implicated in various cellular processes, including gene regulation, DNA replication, and cell signaling. IKZF4 is expressed in various tissues and has been associated with various biological processes, including cell growth, differentiation, and inflammation. In recent years, the research on IKZF4 has gained significant attention due to its potential as a drug target or biomarker. This article will explore the IKZF4 protein, its expression, potential drug targets, and potential use as a biomarker in various diseases.

Structure and Function

The IKZF4 protein is a 24.8 kDa protein that contains 219 amino acid residues. It has a characteristic zinc finger structure, which consists of a nucleotide-binding domain, a zinc finger domain, and a C-terminal domain. The zinc finger domain is responsible for the interaction with zinc ions, which play a crucial role in various cellular processes, including DNA replication, gene regulation, and signaling.

IKZF4 is involved in various cellular processes, including cell growth, differentiation, and inflammation. It has been shown to be involved in the regulation of cell cycle progression, cell survival, and the response to various stimuli, such as UV radiation and chemotherapy [4 ,5]. IKZF4 has also been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases [6,7].

Potential Drug Targets

IKZF4 has been identified as a potential drug target due to its unique structure and function. Its zinc finger domain has been shown to interact with various small molecules, including drugs that are currently being used to treat various diseases. For example, IKZF4 has been shown to interact with inhibitors of the protein kinase kinase A (PKA), which is a known regulator of cell signaling pathways. These interactions may provide a potential mechanism for the efficacy of drugs that are currently used to treat PKA-related diseases, such as hypertension and cardiovascular disease [8,9].

IKZF4 has also been shown to interact with other small molecules that are used to treat various diseases, including cancer and neurodegenerative diseases. For example, IKZF4 has been shown to interact with the inhibitor of DNA-protein binding, which has been shown to be an effective therapeutic agent for the treatment of various cancers, including breast cancer [10,11].

Potential Biomarkers

IKZF4 has also been shown to be potential biomarker for various diseases. Its expression has been shown to be elevated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases [12,13]. The levels of IKZF4 have also been shown to be associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases [14,15].

IKZF4 has been shown to play a crucial role in the regulation of cellular processes, including cell growth, differentiation, and inflammation. Its zinc finger domain has been shown to interact with various small molecules that are involved in these processes. Its expression has also been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. These properties make IKZF4 a potential biomarker for various diseases.

Conclusion

In conclusion, IKZF4 is a unique protein that has been shown to be involved in various cellular processes and has been associated with various diseases. Its zinc finger domain has been shown to interact with various small molecules that are involved in cell signaling pathways, including DNA replication and gene regulation. Its expression has also been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. These properties make IKZF4 a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of IKZF4 in various biological processes and its potential as a drug target and biomarker.

Protein Name: IKAROS Family Zinc Finger 4

Functions: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity)

More Common Targets

IKZF5 | IL-1 Receptor | IL-10 Receptor | IL-11 receptor | IL-12 receptor | IL-13 receptor | IL-15 receptor | IL-17 Receptor | IL-2 receptor | IL-20 receptor | IL-22 Receptor | IL-23 receptor complex | IL-27 receptor | IL-3 receptor | IL-31 Receptor | IL-4 receptor | IL-5 receptor | IL-6 receptor | IL10 | IL10RA | IL10RB | IL10RB-DT | IL11 | IL11RA | IL12A | IL12A-AS1 | IL12B | IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA