KRTAP6-3: A Potential Drug Target and Biomarker (G337968)

Target Name: KRTAP6-3

NCBI ID: G337968

Other Name(s): Keratin associated protein 6-3 | KRA63_HUMAN | keratin associated protein 6-3 | KAP6.3 | Keratin-associated protein 6-3

KRTAP6-3: A Potential Drug Target and Biomarker

Keratin associated protein 6-3 (KRTAP6-3) is a protein that has been identified as a potential drug target and biomarker in the field of skin diseases. KRTAP6-3 is a 21-kDa protein that is expressed in various tissues, including skin, hair, and nails. It is highly expressed in seborrheic keratitis, a common skin disease that affects millions of people worldwide.

The exact function of KRTAP6-3 is not yet fully understood, but it is known to be involved in the regulation of cell growth, differentiation, and survival. It has been shown to play a role in the development and progression of various skin diseases, including seborrheic keratitis.

One of the key reasons for the potential drug target status of KRTAP6-3 is its role in the development of skin cancer. Studies have shown that KRTAP6-3 is highly expressed in skin cancer tissues, and that it is involved in the regulation of cell proliferation and survival. This suggests that KRTAP6-3 may be a useful target for drugs that are designed to inhibit its function in skin cancer.

In addition to its potential role in skin cancer development, KRTAP6-3 has also been shown to be involved in the regulation of skin inflammation. Studies have shown that KRTAP6-3 is highly expressed in inflammatory skin tissues, and that it is involved in the regulation of inflammation response. This suggests that KRTAP6-3 may be a useful target for drugs that are designed to inhibit its function in skin inflammation.

Another potential drug target for KRTAP6-3 is its role in the regulation of skin texture and pigmentation. Studies have shown that KRTAP6-3 is involved in the regulation of skin texture and pigmentation, and that it plays a role in the development of various skin diseases, including melasma. This suggests that KRTAP6-3 may be a useful target for drugs that are designed to inhibit its function in skin texture and pigmentation.

In conclusion, KRTAP6-3 is a protein that has been identified as a potential drug target and biomarker in the field of skin diseases. Its role in the regulation of cell growth, differentiation, and survival, as well as its involvement in the regulation of skin cancer, inflammation, and texture and pigmentation, make it an attractive target for drug development. Further research is needed to fully understand the function of KRTAP6-3 and its potential as a drug target.

Protein Name: Keratin Associated Protein 6-3

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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