FENDRR (Onco-lncRNA-21) as a Drug Target and Biomarker (G400550)
FENDRR (Onco-lncRNA-21) as a Drug Target and Biomarker
Introduction
FENDRR (fenofibrillated 1, 4-butadiene-induced neurotrophic factor receptor) is a non-coding RNA molecule that has been identified as an onco-lncRNA (oncogene-long non-coding RNA) in the brain. This RNA molecule plays a critical role in the development and progression of various neurological diseases, including neurodegenerative disorders, epilepsy, and mood disorders. Therefore, targeting FENDRR as a drug target or biomarker could potentially lead to new therapeutic approaches for these diseases.
FENDRR function and localization
FENDRR is an RNA molecule of a transcription factor gene, mainly expressed in neurons. The promoter of the FENDRR gene has been found to be specifically expressed in brain tissue and significantly expressed in the neuronal cell cycle. In addition, the promoter of the FENDRR gene was also found to be significantly expressed in the brain tissue of epilepsy patients, which provides important clues for studying the role of FENDRR in the pathogenesis of epilepsy.
Function and mechanism of action of FENDRR
FENDRR is a transcription factor that controls gene expression mainly by binding to DNA. Studies have shown that FENDRR can bind to the promoters of certain genes and thereby control the expression of these genes. In addition, FENDRR can also bind to some proteins, thereby affecting the structure and function of these proteins.
FENDRR and neuronal apoptosis
Neuronal apoptosis is an important way of cell death and plays a crucial role in neuronal damage and neurodegenerative diseases. Research shows that FENDRR plays an important role in neuronal apoptosis. Studies have found that FENDRR can inhibit neuronal apoptosis, thereby protecting neurons from damage caused by neurodegenerative diseases.
FENDRR and neuronal growth
Neuronal growth is an important process for restoring function after neuronal injury. Research shows that FENDRR also plays an important role in neuronal growth. Studies have found that FENDRR can promote the growth and regeneration of neurons, thus providing new ideas for the treatment of neuronal damage.
The research significance of FENDRR as a drug target or biomarker
As a new drug target or biomarker, FENDRR has important research significance. First, FENDRR can serve as a potential drug target for the treatment of neurological diseases such as epilepsy. Secondly, FENDRR can serve as an important biomarker for neuronal damage and neurodegenerative diseases, providing important guidance for the diagnosis and treatment of diseases.
in conclusion
FENDRR is an important onco-lncRNA that plays an important role in neuronal apoptosis, growth and function. By targeting FENDRR as a drug target or biomarker, it can potentially lead to new therapeutic approaches for neurodegenerative disorders and other neurological diseases. Further studies are needed to fully understand the role of FENDRR in neurological diseases and as a drug target or biomarker research provides more evidence.
Protein Name: FOXF1 Adjacent Non-coding Developmental Regulatory RNA
More Common Targets
FER | FER1L4 | FER1L5 | FER1L6 | FER1L6-AS1 | FER1L6-AS2 | FERD3L | FERMT1 | FERMT2 | FERMT3 | Ferritin | FES | Fetal Hemoglobin (HbF) | FETUB | FEV | FEZ1 | FEZ2 | FEZF1 | FEZF1-AS1 | FEZF2 | FFAR1 | FFAR2 | FFAR3 | FFAR4 | FGA | FGB | FGD1 | FGD2 | FGD3 | FGD4 | FGD5 | FGD5-AS1 | FGD5P1 | FGD6 | FGF1 | FGF10 | FGF10-AS1 | FGF11 | FGF12 | FGF12-AS2 | FGF13 | FGF13-AS1 | FGF14 | FGF14-AS1 | FGF14-AS2 | FGF14-IT1 | FGF16 | FGF17 | FGF18 | FGF19 | FGF2 | FGF20 | FGF21 | FGF22 | FGF23 | FGF3 | FGF4 | FGF5 | FGF6 | FGF7 | FGF7P3 | FGF7P5 | FGF7P6 | FGF8 | FGF9 | FGFBP1 | FGFBP2 | FGFBP3 | FGFR1 | FGFR1OP2 | FGFR2 | FGFR3 | FGFR3P1 | FGFR4 | FGFRL1 | FGG | FGGY | FGL1 | FGL2 | FGR | FH | FHAD1 | FHDC1 | FHF Complex | FHIP1A | FHIP1B | FHIP2A | FHIP2B | FHIT | FHL1 | FHL2 | FHL3 | FHL5 | FHOD1 | FHOD3 | FIBCD1 | FIBIN | FIBP | Fibrinogen | Fibroblast growth factor (FGF)
