Fetuin B: A Protein Interactions and Cancer Target with Significant Implications

Fetuin B: A Protein Interactions and Cancer Target with Significant Implications

Fetuin B, also known as FETUB (Fetuin B, transcript variant 1), is a protein that is expressed in various tissues throughout the body, including the liver, heart, kidneys, and pancreas. It is a member of the integrin family, which is a large superfamily of transmembrane proteins that play a critical role in cell-cell and cell-extracellular matrix interactions.

One of the unique features of fetuin B is its ability to interact with integrins on the surface of cancer cells. This interaction allows the cancer cells to stick to the blood vessels and form tumors. Additionally, fetuin B has also been shown to play a role in the regulation of cell adhesion, which is critical for the development and progression of many diseases, including cancer.

Fetuin B has also been shown to be involved in the regulation of the immune response. Studies have shown that fetuin B can modulate the activity of natural killer cells, which are important for immune surveillance against cancer. Additionally, fetuin B has also been shown to play a role in the regulation of the inflammatory response, which is important for the development of many diseases, including cancer.

Fetuin B is also a potential drug target for several diseases, including cancer. Studies have shown that inhibiting fetuin B can lead to the regression of cancer tumors in both pre- and post-clinical models. Additionally, a small molecule inhibitor of fetuin B has been shown to be effective in treating several types of cancer, including breast, lung, and colorectal cancer.

In addition to its potential as a drug target, fetuin B is also a potential biomarker for cancer. Studies have shown that fetuin B levels can be used as a diagnostic marker for several types of cancer, including breast, lung, and colorectal cancer. Additionally, levels of fetuin B have also been shown to be elevated in the blood of patients with cancer, making it a potential indicator of the disease.

Overall, fetuin B is a protein that has significant implications for the development and treatment of cancer. Its ability to interact with integrins on the surface of cancer cells, as well as its involvement in the regulation of cell adhesion and the immune response, make it a potential drug target and biomarker for cancer. Further research is needed to fully understand the role of fetuin B in cancer biology and to develop effective treatments.

Protein Name: Fetuin B

Functions: Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)

More Common Targets

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