Target Name: FILIP1L
NCBI ID: G11259
Other Name(s): Filamin A interacting protein 1 like, transcript variant 1 | GIP130b | Filamin A-interacting protein 1-like (isoform 1) | Downregulated in ovarian cancer 1 81 kDa isoform | 90 kDa GPBP-interacting protein | Filamin A interacting protein 1 like, transcript variant 2 | FILIP1L variant 2 | protein down-regulated in ovarian cancer 1 | DOC1 | GPBP-interacting protein 90 | Filamin A-interacting protein 1-like (isoform 3) | 130 kDa GPBP-interacting protein | FILIP1L variant 1 | OTTHUMP00000213949 | DOC-1 | FIL1L_HUMAN | Filamin A interacting protein 1 like, transcript variant 3 | Filamin A-interacting protein 1-like | Protein down-regulated in ovarian cancer 1 | filamin A interacting protein 1 like | Filamin A-interacting protein 1-like isoform 1 | GPBP-interacting protein of 130 kDa | FILIP1L variant 3 | COL4A3BPIP | Filamin A-interacting protein 1-like (isoform 2) | GIP130 | GIP90 | GIP130c

FILIP1L: A Potential Drug Target and Biomarker for Filmin-Interactive Protein 1-like

Abstract:

FILIP1L (Filamin A interacting protein 1 like, transcript variant 1) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure, expressed in various tissues and cellular compartments, and its putative role in regulating various cellular processes make it an attractive target for drug development. In this article, we will provide an overview of FILIP1L, its functions, potential drug targets, and potential biomarkers.

Introduction:

FILIP1L is a protein that is expressed in various tissues and cellular compartments, including muscle, heart, brain, and organs. It is a member of the Filamin family, which includes several similar proteins that are involved in the regulation of cell-cell interactions and the structure of the cytoskeleton. FILIP1L is unique in that it has a distinct N-terminus and a unique C-terminus, which are not found in other proteins.

Function and Diverse Roles in Cellular Processes:

FILIP1L plays a role in various cellular processes, including cytoskeleton organization, cell-cell adhesion, and intracellular signaling pathways. It is involved in the regulation of the actin cytoskeleton, which is responsible for cell movement and mechanical forces. FILIP1L is also involved in the regulation of the endoplasmic reticulum (ER), which is responsible for the delivery and retrieval of proteins from the cytoplasm to the cell surface.

Potential Drug Targets:

FILIP1L has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. Several studies have shown that FILIP1L can interact with various drugs, including inhibitors of tyrosine kinase activity and inhibitors of protein-protein interactions. These interactions suggest that FILIP1L may be a useful target for drug development for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Potential Biomarkers:

FILIP1L has also been identified as a potential biomarker for various diseases. Its unique structure and various functions make it an attractive target for diagnostic tools, including protein arrays and antibodies. Several studies have shown that FILIP1L is expressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. These findings suggest that FILIP1L may be a useful biomarker for the diagnosis and treatment of various diseases.

Conclusion:

FILIP1L is a protein that has been identified as a potential drug target and biomarker for various diseases. Its unique structure and various functions make it an attractive target for drug development. Further research is needed to fully understand the functions and potential drug targets of FILIP1L.

Protein Name: Filamin A Interacting Protein 1 Like

Functions: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature

More Common Targets

FILNC1 | FIP1L1 | FIRRE | FIS1 | FITM1 | FITM2 | Five friends of methylated CHTOP complex | FIZ1 | FJX1 | FKBP10 | FKBP11 | FKBP14 | FKBP15 | FKBP1A | FKBP1A-SDCBP2 | FKBP1B | FKBP1C | FKBP2 | FKBP3 | FKBP4 | FKBP5 | FKBP6 | FKBP7 | FKBP8 | FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3 | FMO4 | FMO5 | FMO6P | FMO9P | FMOD | FMR1 | FMR1-AS1 | FMR1NB | FN1