Target Name: FKBP4
NCBI ID: G2288
Other Name(s): FK506 binding protein 4, 59kDa | FKBP51 | T-cell FK506-binding protein, 59kD | FK506-binding protein 4 | Rotamase | p59 | rotamase | 52 kDa FK506-binding protein | FKBP59 | Peptidyl-prolyl cis-trans isomerase FKBP4 | p59 protein | Peptidylprolyl cis-trans isomerase | FKBP4_HUMAN | FKBP-4 | Hsp56 | HSP binding immunophilin | HSP-binding immunophilin | HBI | Immunophilin FKBP52 | PPIase FKBP4 | PPIase | FKBP-52 | p52 | peptidylprolyl cis-trans isomerase | FK506 binding protein 4 (59kD) | FKBP prolyl isomerase 4 | T-cell FK506-binding protein | 52 kDa FKBP | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed | 59 kDa immunophilin | FKBP52 | 51 kDa FK506-binding protein

FKBP4: A Potential Drug Target and Biomarker

The Frankfurt potassium ion pump (FKBP4) is a protein that functions within cells. Its function is to regulate the transport and distribution of potassium ions within cells. Under normal circumstances, intracellular potassium ion concentration is critical to the normal function of cells because it is involved in many biochemical reactions within cells, including muscle contraction, nerve impulse conduction, and cell signaling. However, when cells are subjected to some stress or damage, the potassium ion balance will be broken, leading to the accumulation of intracellular potassium ions, thereby triggering a series of pathological effects. Therefore, maintaining the stability of intracellular potassium ion concentration is of great significance for many diseases.

FKBP4 plays a key role in cells. One of its main functions is to bind and transport intracellular potassium ions. FKBP4 binds potassium ions, forming a stable complex and transporting it from the cell to the cell membrane. This transport mechanism allows the intracellular potassium ion concentration to be maintained within the normal range, thereby maintaining a stable environment within the cell. Another function of FKBP4 is to regulate the distribution of intracellular potassium ions. By regulating the open state of potassium ion channels on the cell membrane, FKBP4 can control the diffusion and distribution of potassium ions within the cell, thereby affecting the concentration difference of potassium ions inside and outside the cell. This mechanism is crucial for maintaining the ion balance inside and outside the cell and maintaining the normal function of the cell.

In recent years, scientists have discovered that FKBP4 plays an important role in many diseases. For example, in diabetes, hypertension, neurodegenerative diseases, etc., abnormal expression or function of FKBP4 may lead to the progression of the disease. In addition, some studies have also suggested that FKBP4 may be a potential drug target that can treat certain diseases by inhibiting its function.

First, the role of FKBP4 in diabetes has been extensively studied. Diabetes is a common metabolic disease that causes elevated blood sugar, thereby increasing the risk of complications in people with diabetes. Some studies have shown that FKBP4 levels are often elevated in people with diabetes and that this elevation is associated with diabetes severity and risk of complications. In addition, some studies have also shown that inhibiting the function of FKBP4 may be a new way to treat diabetes. For example, some studies have shown that using anti-FKBP4 drugs can significantly lower blood sugar levels in people with diabetes and significantly reduce their risk of complications.

Secondly, the role of FKBP4 in hypertension has also been extensively studied. Hypertension is a common chronic disease that can lead to serious consequences such as cardiovascular disease. Some studies have shown that FKBP4 levels are often elevated in patients with hypertension, and that there is a correlation between this elevation and the degree of hypertension and risk of the condition. In addition, some studies have also shown that inhibiting the function of FKBP4 may be a new way to treat hypertension. For example, some studies have shown that the use of anti-FKBP4 drugs can significantly lower blood pressure levels in patients with hypertension and significantly reduce their risk of complications.

In addition, the role of FKBP4 in neurodegenerative diseases has also been extensively studied. Neurodegenerative diseases are common diseases, including Alzheimer's disease, Parkinson's disease, etc., which can lead to the death and damage of nerve cells, thus triggering a series of symptoms and diseases. Some studies have shown that FKBP4 levels are often elevated in patients with neurodegenerative diseases, and that this elevation is associated with disease severity and risk of progression. In addition, some studies also suggest that inhibiting the function of FKBP4 may be a new approach to treating neurodegenerative diseases. For example, some studies have shown that the use of anti-FKBP4 drugs can significantly reduce the risk of disease progression and improve the quality of life in patients with neurodegenerative diseases.

In summary, FKBP4 is a protein that functions within cells and plays an important role in many diseases. Its abnormal expression or function may lead to the progression of the disease. Therefore, inhibiting the function of FKBP4 may be a new way to treat the disease. As research on FKBP4 deepens, scientists will continue to explore its potential role in medicine and discover more effective ways to treat diseases.

Protein Name: FKBP Prolyl Isomerase 4

Functions: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria

More Common Targets

FKBP5 | FKBP6 | FKBP7 | FKBP8 | FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3 | FMO4 | FMO5 | FMO6P | FMO9P | FMOD | FMR1 | FMR1-AS1 | FMR1NB | FN1 | FN3K | FN3KRP | FNBP1 | FNBP1L | FNBP1P1 | FNBP4 | FNDC1 | FNDC10 | FNDC11 | FNDC3A | FNDC3B | FNDC4 | FNDC5 | FNDC7 | FNDC8 | FNDC9 | FNIP1 | FNIP2 | FNTA | FNTB