FLNC: A Scaffold Protein That Regulates Cell-Cell Adhesion and Communication

Target Name: FLNC

NCBI ID: G2318

FLNC: A Scaffold Protein That Regulates Cell-Cell Adhesion and Communication

FLNC (Factorless Ligand-Conjugated scaffold) is a protein that is expressed in various cell types of the human body, including endothelial cells, pericytes, and epithelial cells. It is a scaffold protein that plays a crucial role in the regulation of cell-cell adhesion, as well as the formation of tight junctions and adherens junctions.

FLNC is a member of the integrin family, which is a large family of transmembrane proteins that play a central role in various cellular processes, including cell adhesion, migration, and signaling. Integrins are involved in the formation of tight junctions and adherens junctions, which are complex structures that mediate cell-cell communication and help to maintain tissue structure and integrity.

FLNC is characterized by its unique structure, which consists of a long arm that is held in a constant state by a network of multiple interaction domains. This arm is held in a bent shape, which allows it to interact with various cell surface molecules, including cadherins, integrins, and other scaffold proteins.

FLNC has been shown to play a crucial role in the regulation of cell-cell adhesion and the formation of tight junctions and adherens junctions. It is a key regulator of the cadherin-based signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and survival.

FLNC has also been shown to be involved in the regulation of cell migration and the maintenance of tissue structure. It helps to maintain the integrity of tissues by preventing the formation of gaps between cells, which can lead to the loss of cell-cell adhesion and the formation of gaps between tissues.

FLNC is also involved in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key regulator of tissue growth and development.

FLNC has also been shown to play a role in the regulation of inflammation and immune responses. It is involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-伪 and IL-1尾, as well as the regulation of the production of anti-inflammatory cytokines, such as IL-10.

In conclusion, FLNC is a protein that plays a crucial role in the regulation of cell-cell adhesion, the formation of tight junctions and adherens junctions, and the regulation of cell signaling pathways, including the TGF-β pathway. It is a potential drug target and a biomarker for various diseases, including cancer, cardiovascular disease, and autoimmune disorders. Further research is needed to fully understand the role of FLNC in cellular processes and its potential as a drug target.

Protein Name: Filamin C

Functions: Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity)

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