FLRT2: A Potential Drug Target Or Biomarker for Various Diseases

Target Name: FLRT2

NCBI ID: G23768

Other Name(s): FLRT2_HUMAN | Fibronectin leucine rich transmembrane protein 2 | FLRT2 variant 3 | Leucine-rich repeat transmembrane protein FLRT2 | Fibronectin leucine rich transmembrane protein 2, transcript variant 3 | fibronectin-like domain-containing leucine-rich transmembrane protein 2 | KIAA0405 | Fibronectin leucine rich transmembrane protein 2, transcript variant 1 | fibronectin leucine rich transmembrane protein 2 | FLRT2 variant 1 | Fibronectin-like domain-containing leucine-rich transmembrane protein 2 | Leucine-rich repeat transmembrane protein FLRT2 [Precursor]

FLRT2: A Potential Drug Target Or Biomarker for Various Diseases

FLRT2 (FLRT2_HUMAN), a gene that encodes a protein known as FLRT2, has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The FLRT2 gene was first identified in 2008 using DNA-based approaches. The gene is located on chromosome 16 and encodes a protein that is expressed in various tissues and organs, including the brain, spinal cord, and peripheral tissues.

FLRT2 is a transmembrane protein that is characterized by its unique topology. It consists of a catalytic center, a transmembrane region, and an optional cytoplasmic tail. The protein is involved in various cellular processes, including cell signaling, DNA replication, and metabolism.

FLRT2 has been shown to play a role in various diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of FLRT2 are associated with poor prognosis in patients with pancreatic cancer, a leading cause of cancer-related mortality.

In addition to its potential as a drug target, FLRT2 has also been identified as a potential biomarker for various diseases. For example, researchers have shown that FLRT2 levels can be used as a diagnostic marker for neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

FLRT2 has also been shown to play a role in the development and progression of certain autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. In these conditions, the immune system attacks the body's own tissues, leading to inflammation and damage.

In conclusion, FLRT2 is a gene that has the potential to be a drug target or biomarker for various diseases. Further research is needed to fully understand its role in these conditions and to develop effective treatments.

Protein Name: Fibronectin Leucine Rich Transmembrane Protein 2

Functions: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis

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