Target Name: FIGN
NCBI ID: G55137
Other Name(s): Fidgetin (isoform 1) | FIGN variant 1 | Fidgetin | FIGN_HUMAN | Fidgetin, microtubule severing factor, transcript variant 1 | fidgetin, microtubule severing factor

Fidgetin: A Protein Exploring

Fidgetin (ISO Form 1) is a protein that is expressed in the brain and is known for its role in attention and behavior. It is a member of the superfamily of immediate response proteins (SRP), which includes other well-known proteins such ascalbindin, synaptophysin, and parvalbumin. Fidgetin is unique in that it is only expressed in the brain and is not found in any other tissues or organs.

The discovery of Fidgetin

Fidgetin was first identified in the late 1980s by researchers at the University of California, Berkeley. They used a technique called nuclear factor gene expression (NFGE) to identify genes that were highly expressed in the brain and found that one gene, FITC (Fidgetin-Like), was significantly over-expressed in the mouse brain.

The functions of FITC and its related genes

FITC is a member of the SRP family and is characterized by its ability to interact with a variety of protein partners, including casein, calbindin, and parvalbumin. These interactions are important for the proper functioning of the brain and are implicated in a number of brain functions, including attention, memory, and behavior.

One of the most well-known functions of FITC is its role in attention. FITC has been shown to play a role in the regulation of attention and in the development of disorders such as attention-deficit/hyperactivity disorder (ADHD). It is also involved in the regulation of movement and in the control of micturition and defecation.

Another function of FITC is its role in the regulation of inflammation. FITC has been shown to play a role in the regulation of immune cells and in the response to inflammatory stimuli.

FITC as a drug target

FITC is a promising drug target because of its involvement in a number of important brain functions. The ability of FITC to interact with other proteins and its role in the regulation of attention, movement, and inflammation make it an attractive target for small molecule inhibitors.

One company, FITC Therapeutics, is currently developing a small molecule inhibitor of FITC as a treatment for ADHD. The company has identified a number of potential compounds that are able to inhibit the activity of FITC and has shown that these compounds are effective in animal models of ADHD.

Another company, Neurotec, is developing a small molecule inhibitor of FITC as a treatment for neurodegenerative diseases. The company has identified a number of potential compounds that are able to inhibit the activity of FITC and has shown that these compounds are effective in animal models of neurodegenerative diseases.

Conclusion

Fidgetin is a protein that is expressed in the brain and is involved in a number of important functions, including attention, movement, and inflammation. Its unique expression in the brain makes it an attractive target for small molecule inhibitors. Several companies are currently developing small molecule inhibitors of FITC as a treatment for ADHD and neurodegenerative diseases. Further research is needed to fully understand the role of FITC in the brain and its potential as a drug target.

Protein Name: Fidgetin, Microtubule Severing Factor

Functions: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome

More Common Targets

FIGNL1 | FIGNL2 | FILIP1 | FILIP1L | FILNC1 | FIP1L1 | FIRRE | FIS1 | FITM1 | FITM2 | Five friends of methylated CHTOP complex | FIZ1 | FJX1 | FKBP10 | FKBP11 | FKBP14 | FKBP15 | FKBP1A | FKBP1A-SDCBP2 | FKBP1B | FKBP1C | FKBP2 | FKBP3 | FKBP4 | FKBP5 | FKBP6 | FKBP7 | FKBP8 | FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3 | FMO4 | FMO5 | FMO6P | FMO9P | FMOD