FGF2: Crucial Role in Cell Growth and Development (G2247)

Target Name: FGF2

NCBI ID: G2247

FGF2: Crucial Role in Cell Growth and Development

Fibroblast growth factor 2 (FGF2) is a protein that plays a crucial role in cell growth and development. It is a member of the fibroblast growth factor family, which is a group of proteins that promote cell growth and differentiation. FGF2 is often used as a drug target or biomarker because of its ability to stimulate cell proliferation and migration.

The fibroblast growth factor family consists of seven transmembrane proteins, including FGF1, FGF2, FGF3, FGF4, FGF5, FGF6, and FGF7. These proteins are involved in the development and maintenance of tissues and organs, including bone, cartilage, and skin. FGF2 is one of the most well-studied members of the family, and its role in cell growth and development has been extensively investigated.

FGF2 is a potent motivator for cell proliferation and migration. It has been shown to stimulate the growth and migration of a wide variety of cell types, including fibroblasts, neurons, and endothelial cells. FGF2 has been shown to promote the formation of new blood vessels, which is essential for the growth and development of tissues. It has also been shown to play a role in the development and maintenance of tissues and organs, including bone, cartilage, and skin.

FGF2 has also been shown to be involved in several signaling pathways. It is a potent activator of the TGF-β pathway, which is a well-known signaling pathway that is involved in the development and maintenance of tissues and organs. The TGF-β pathway is responsible for promoting cell proliferation, differentiation, and tissue repair. FGF2 has also been shown to be involved in the FGF-1/2 signaling pathway, which is involved in the regulation of cell growth and differentiation.

FGF2 has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues and organs. It has been shown to promote the production of extracellular matrix (ECM) components, such as collagen and elastin, which are important for the formation of tissues and organs. FGF2 has also been shown to promote the production of growth factors, such as platelet-derived growth factor (PDGF), which is important for the growth and development of tissues and organs.

FGF2 has also been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of tissues and organs. It has been shown to promote the production of cell adhesion molecules, such as E-cadherin, which are important for the formation of tissues and organs. FGF2 has also been shown to promote the production of tight junction proteins, such as tight junction protein 1 (TJP1), which is important for the regulation of cell-cell communication and the formation of tissues and organs.

FGF2 has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues and organs. It has been shown to promote the production of genes involved in the regulation of cellular processes, such as cell cycle genes and apoptosis genes. FGF2 has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues and organs. It has been shown to promote the production of genes involved in the regulation of cellular processes, such as cell cycle genes and apoptosis genes.

In conclusion, FGF2 is a protein that plays a crucial role in cell growth and development. It is a member of the fibroblast growth factor family and has been shown to be involved in several signaling pathways that are important for the development and maintenance of tissues and organs. Its ability to stimulate cell proliferation and migration makes it an attractive drug target or biomarker for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of FGF2 in cell growth and development and to develop new treatments based on its properties.

Protein Name: Fibroblast Growth Factor 2

Functions: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879)

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