Fumarate Hydratase: A Promising Drug Target and Biomarker (G2271)

Target Name: FH

NCBI ID: G2271

Fumarate Hydratase: A Promising Drug Target and Biomarker

Fumarate hydratase (FH) is an enzyme that plays a crucial role in the production of fumaric acid, a compound that is known for its role in a variety of cellular processes. Fumaric acid has been shown to be involved in a wide range of biological processes, including cellular signaling, inflammation, and tissue repair. As a result, FH has become a promising drug target and biomarker for a variety of diseases.

The discovery and characterization of FH

Fumarate hydratase was first identified in the 1970s by researchers who were studying the metabolism of tryptophan, a amino acid that is involved in the production of neurotransmitters. They found that the enzyme responsible for breaking down tryptophan was similar to a group of enzymes that they had identified in the previous years as fumarate synthases. These enzymes were characterized as FH1, FH2, and FH3, and they were shown to catalyze the synthesis of fumaric acid from tryptophan.

Since then, more research has been conducted on FH, and it has been found to play a much broader role in the production of fumaric acid. FH is involved in the synthesis of many different compounds that are involved in cellular signaling and other processes. For example, FH is used in the production of collagen, a protein that is involved in tissue repair and growth. It is also involved in the production of hyaluronic acid, a component of connective tissue extracellular matrix.

FH is also involved in the production of other compounds that are involved in inflammation and cellular signaling. For example, FH has been shown to be involved in the production of pro-inflammatory cytokines, such as TNF-alpha and IL-1. It is also involved in the production of anti-inflammatory compounds, such as IL-10.

Drug targeting and biomarker potential

FH has been shown to be a promising drug target for a variety of diseases. Because FH is involved in the production of many different compounds that are involved in cellular signaling and other processes, it is possible to target FH with drugs that inhibit its activity. For example, inhibitors of FH have been shown to be effective in treating a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

In addition to its potential as a drug, FH is also a promising biomarker for a variety of diseases. Because FH is involved in the production of many different compounds that are involved in cellular signaling and other processes, it is possible to use FH as a marker for the presence or activity of these compounds. For example, FH has been shown to be involved in the production of TNF-alpha, a cytokine that is involved in inflammation and tissue damage. As a result, FH has been used as a biomarker for a variety of inflammatory diseases, including cancer and autoimmune disorders.

FH is also involved in the production of hyaluronic acid, a component of connective tissue extracellular matrix. As a result, FH has been shown to be involved in the development and progression of a variety of diseases, including cancer and neurodegenerative disorders. This makes FH an attractive biomarker for these diseases as well.

Conclusion

Fumarate hydratase (FH) is an enzyme that plays a crucial role in the production of fumaric acid, a compound that is involved in a wide range of cellular processes. FH has been shown to be involved in the production of many different compounds that are involved in cellular signaling and other processes, including the production of collagen, hyaluronic acid, and other compounds involved in inflammation and tissue repair. As a result, FH has become a promising drug target and biomarker for a variety of diseases.

Protein Name: Fumarate Hydratase

Functions: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)

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