LY9: A Protein with Multiple Functions and Potential as A Drug Target

Target Name: LY9

NCBI ID: G4063

LY9: A Protein with Multiple Functions and Potential as A Drug Target

LY9 (mLY9) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the mucin family, which is a group of transmembrane proteins that play a critical role in cell -cell and cell-extracellular matrix interactions.

One of the unique features of LY9 is its ability to interact with integrins, which are proteins that are found on the surface of many different cell types. Integrins are responsible for cell-cell adhesion, and they play a key role in the development and maintenance of tissues and organs. By interacting with integrins, LY9 is able to influence the movement and behavior of cells, which is essential for many different cellular processes.

Another important function of LY9 is its role in the regulation of cell growth. cells. LY9 has been shown to play a negative role in the growth of cancer cells, which is one of the main reasons why it is considered a potential drug target.

LY9 is also involved in the regulation of cell death, which is another important function of the protein. When cells are no longer needed or are damaged, LY9 helps to facilitate the process of cell death, which is essential for maintaining tissue homeostasis and for the development and maintenance of tissues.

LY9 is also involved in the regulation of inflammation, which is a critical function of many different cell types. It has been shown to play a key role in the regulation of immune responses, as well as in the regulation of inflammation that can be caused by harmful substances.

In addition to its role in cell biology, LY9 is also of interest as a potential drug target because of its ability to interact with a wide range of different proteins. This makes it an attractive target for researchers who are looking for new ways to treat a variety of different diseases.

Overall, LY9 is a protein that has important functions in many different cellular processes, and it is of interest as a potential drug target. Further research is needed to fully understand the role of LY9 in cell biology and its potential as a drug.

Protein Name: Lymphocyte Antigen 9

Functions: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity)

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