MAGEA4: Potential Drug Target and Protein Interaction (G4103)

Target Name: MAGEA4

NCBI ID: G4103

MAGEA4: Potential Drug Target and Protein Interaction

MAGEA4 (MAGE-41) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the MAGE family of proteins, which are known for their ability to interact with the sugar molecule, N-acetylglucoside (NAcG).

MAGEA4 is involved in a number of different processes in the body, including inflammation, cell signaling, and tissue repair. It has been shown to play a role in the development and progression of a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of MAGEA4 is its ability to interact with NAcG. This interaction allows MAGEA4 to influence the activity of a protein called GLUT4, which is involved in glucose metabolism. MAGEA4 has been shown to play a role in regulating GLUT4 activity and in the regulation of glucose metabolism.

In addition to its role in glucose metabolism, MAGEA4 is also involved in the regulation of a number of other processes in the body, including inflammation, cell signaling, and tissue repair. It has been shown to play a role in the development and progression of a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

MAGEA4 is also a potential drug target. Researchers have identified a number of small molecules that have been shown to interact with MAGEA4 and are potential candidates for use as drugs. These molecules include inhibitors of GLUT4, as well as molecules that can modulate the activity of MAGEA4.

One of the challenges in the development of MAGEA4 as a drug target is the lack of understanding of its precise mechanism of action. While MAGEA4 has been shown to play a role in a number of different processes in the body, it is not clear how it interacts with the various molecules that are involved in these processes.

In conclusion, MAGEA4 is a protein that is involved in a number of different processes in the body, including inflammation, cell signaling, and tissue repair. It has been shown to play a role in the development and progression of a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its ability to interact with the sugar molecule, NAcG, makes it a potential drug target, and research is ongoing to determine its precise mechanism of action.

Protein Name: MAGE Family Member A4

Functions: Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486)

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