MAGEB2: A Protein Involved in Various Cellular Processes and Disease

Target Name: MAGEB2

NCBI ID: G4113

MAGEB2: A Protein Involved in Various Cellular Processes and Disease

MAGEB2, or MAGE family member B2, is a protein that is expressed in various tissues throughout the body. It is a key component of the MAGE superfamily, which is characterized by the presence of a specific domain in the extracellular domain of the protein that is responsible for its unique structure and function.

MAGEB2 is a 21-kDa protein that is expressed in a variety of tissues, including the liver, spleen, and heart. It is primarily localized to the cytoplasm of cells, where it can be detected using techniques such as immunofluorescence or Western blotting.

One of the unique features of MAGEB2 is its ability to interact with other proteins. It has been shown to interact with a variety of proteins, including the transcription factor NF-kappa-B and the protein T-cell factor 2 (T-CF2). These interactions play a role in the regulation of various cellular processes, including inflammation, stress responses, and cell signaling.

Another key feature of MAGEB2 is its role in the development and progression of certain diseases. For example, MAGEB2 has been shown to be involved in the development of cancer, with studies showing that it is expressed in a variety of cancer types and that it plays a role in the regulation of cell proliferation.

In addition to its role in disease, MAGEB2 has also been shown to have potential as a drug target. Several studies have shown that MAGEB2 can be targeted by small molecules, including inhibitors of its interaction with T-CF2. These inhibitors have been shown to have a variety of therapeutic effects, including the inhibition of cancer cell proliferation and the inhibition of the development of neurodegenerative diseases.

Another approach to targeting MAGEB2 is to use antibodies that recognize specific epitopes on the protein. This approach has been shown to be effective in a variety of settings, including the inhibition of MAGEB2-mediated signaling pathways and the inhibition of the development of cancer.

In conclusion, MAGEB2 is a protein that is expressed in a variety of tissues and is involved in a number of cellular processes. Its unique structure and function, as well as its ability to interact with other proteins, make it a promising target for small molecules and antibodies. Further research is needed to fully understand the role of MAGEB2 in disease and to develop effective therapies based on its properties.

Protein Name: MAGE Family Member B2

Functions: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex

More Common Targets