MAGED4: A Unique GPCR Protein with Potential as A Drug Target and Biomarker

Target Name: MAGED4

NCBI ID: G728239

MAGED4: A Unique GPCR Protein with Potential as A Drug Target and Biomarker

MAGED4 (MAGE1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that play an important role in cellular signaling.

One of the unique features of MAGED4 is its structure. It consists of a single transmembrane domain and a single intracellular loop, which is located at the cytoplasmic side of the membrane. This unique arrangement allows MAGED4 to interact directly with its ligands, which are proteins that fit into the same transmembrane domain.

MAGED4 is involved in a wide range of physiological processes in the body, including cell signaling, neurotransmission, and blood pressure regulation. It is a potent modulator of the blood pressure, and it has been shown to play a role in the development of hypertension.

MAGED4 is also a potential drug target. Several studies have suggested that MAGED4 may be a good candidate for targeting in order to treat hypertension and other conditions that are characterized by elevated blood pressure. This is because MAGED4 is known to be involved in the regulation of blood pressure, and targeting it may allow researchers to develop new treatments for these conditions.

One of the challenges in studying MAGED4 is its expression. While it is widely expressed in many different tissues of the body, it is not highly expressed in any one particular organ or tissue. This makes it difficult to study its effects in a specific context. However, researchers have been able to use techniques such as RNA interference and live cell imaging to study its effects in different contexts.

In addition to its potential as a drug target, MAGED4 is also of interest as a biomarker. Its expression is highly sensitive to changes in blood pressure, which makes it a potential indicator of the health of an individual's blood vessels. This makes it a promising candidate for use as a diagnostic tool in cases of hypertension and other conditions that are characterized by elevated blood pressure.

Overall, MAGED4 is a protein that is of great interest to researchers because of its unique structure and its involvement in a wide range of physiological processes. While it is still a relatively little-studied protein, its potential as a drug target and biomarker makes it a promising candidate for further research.

Protein Name: MAGE Family Member D4

Functions: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex

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