CDCD88C Plays A Key Role in Cell Signaling and Adhesion (G440193)

Target Name: CCDC88C

NCBI ID: G440193

CDCD88C Plays A Key Role in Cell Signaling and Adhesion

CCDC88C (KIAA1509) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and liver. It is a member of the KIAA family of proteins, which are known for their role in cell signaling. In particular, CCDC88C is a key regulator of the Wnt signaling pathway, a critical pathway that regulates cell growth, differentiation, and survival.

The Wnt signaling pathway is a complex system that involves the interactions of various proteins, including Wnt, FBN1, and LRP. Wnt is a transmembrane protein that is involved in the development and maintenance of tissues, including the nervous system and the placenta. FBN1 is a protein that is known for its role in blood clotting, and LRP is a protein that is involved in the production of the laminin protein.

In addition to its role in regulating the Wnt signaling pathway, CCDC88C has also been shown to play a key role in the regulation of cell signaling pathways that are involved in cell growth, differentiation, and survival. For example, studies have shown that CCDC88C can interact with the protein PIK3CA, which is involved in the regulation of cell growth and survival.

In addition to its role in cell signaling, CCDC88C has also been shown to play a key role in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. CCDC88C is involved in the regulation of cell adhesion by interacting with the protein cadherin, which is a transmembrane protein that is involved in cell adhesion.

CDC88C has also been shown to play a key role in the regulation of cell migration. Migration is the process by which cells move from one location to another in the body. CCDC88C is involved in the regulation of cell migration by interacting with the protein vimentin, which is involved in the formation of blood vessels.

In addition to its role in cell signaling and adhesion, CCDC88C has also been shown to play a key role in the regulation of cell proliferation. Proliferation is the process by which cells divide and produce new cells. CCDC88C is involved in the regulation of cell proliferation by interacting with the protein cyclin D1, which is involved in the cycle of cell division.

In conclusion, CCDC88C (KIAA1509) is a protein that is involved in the regulation of various cell signaling pathways, including the Wnt signaling pathway, cell adhesion, migration, and proliferation. Its role in these processes makes CCDC88C an attractive drug target or biomarker for the development of new therapies for a variety of diseases.

Protein Name: Coiled-coil Domain Containing 88C

Functions: Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426)

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