Target Name: CCNH
NCBI ID: G902
Other Name(s): CAK complex subunit | cyclin-dependent kinase-activating kinase complex subunit | Cyclin-H (isoform 1) | p34 | CDK-activating kinase | p37 | CCNH variant 1 | Cyclin H, transcript variant 2 | CAK | MO15-associated protein | CCNH_HUMAN | CCNH variant 2 | Cyclin-dependent kinase-activating kinase complex subunit | cyclin H | Cyclin H, transcript variant 1 | CDK-activating kinase complex subunit | Cyclin-H | Cyclin H | CycH | Cyclin-H isoform 2

CCNH Subunit: A Potential Drug Target and Biomarker

The CCNH (Ca+-calmodulin-dependent neurotransmitter release) complex is a protein complex that is involved in the release of neurotransmitters from neurons. This complex is composed of multiple subunits, including the subunit CCNH伪, which is a key component of the complex.

The CCNH伪 subunit is a protein that is composed of two interacting subunits. One is the N-terminal 伪-helix, which can bind Ca2+ ions, thereby enhancing the ability of neurons to release neurotransmitters. The other is the C-terminal alpha helix, which binds a small molecule called a "release factor" to promote the release of neurotransmitters.

The structure and function of the CCNH伪 subunit are highly conserved, and its ability to bind to other neuron-specific receptors suggests that it may be a potential drug target or biomarker.

Currently, researchers are exploring the possibility of CCNH伪 subunit as a drug target. Some studies have shown that the CCNH伪 subunit can interact with a variety of drugs and can affect these drugs by modulating the way neurons release neurotransmitters. These findings have drawn researchers' attention to the CCNH伪 subunit and may provide new directions for future drug research.

In addition to being a drug target, CCNH伪 subunit may also be a biomarker. By detecting the expression levels of the CCNH伪 subunit in neurons, researchers can assess the health of neuronal function. This method could be used to assess neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In addition, the CCNH伪 subunit can also be used as an indicator of synaptic accessibility of neurons to assess the health of neuronal function by measuring the synaptic accessibility between neurons.

In addition to potential applications in drug research and biomarker studies, the structure of the CCNH伪 subunit also has important implications for its function. Since the N-terminal 伪-helix of CCNH伪 subunit is the key site for binding Ca2+ ions, researchers are exploring ways to regulate neuronal release of neurotransmitters by regulating Ca2+ ion concentration. These studies may provide new insights for future neuroscience research.

Protein Name: Cyclin H

Functions: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle

More Common Targets

CCNI | CCNI2 | CCNJ | CCNJL | CCNK | CCNL1 | CCNL2 | CCNO | CCNP | CCNQ | CCNQP1 | CCNT1 | CCNT2 | CCNT2-AS1 | CCNT2P1 | CCNY | CCNYL1 | CCNYL2 | CCP110 | CCPG1 | CCR1 | CCR10 | CCR12P | CCR2 | CCR3 | CCR4 | CCR4-NOT transcription complex | CCR5 | CCR5AS | CCR6 | CCR7 | CCR8 | CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1