Target Name: CCR8
NCBI ID: G1237
Other Name(s): CC chemokine receptor CHEMR1 | chemokine receptor-like 1 | Chemokine (C-C) receptor 8 | chemokine (C-C) receptor-like 2 | Chemokine receptor-like 1 | CC-chemokine receptor chemr1 | CC-CKR-8 | GPRCY6 | CDw198 | chemokine (C-C motif) receptor 8 | CMKBR8 | Chemokine (C-C) receptor-like 2 | chemokine (C-C) receptor 8 | CMKBRL2 | C-C CKR-8 | CCR-8 | CCR8_HUMAN | Chemokine (C-C motif) receptor 8 | CKR-L1 | C-C motif chemokine receptor 8 | CC chemokine receptor 8 | GPR-CY6 | CY6 | C-C chemokine receptor type 8 | CKRL1 | TER1

CCR8: A Protein Implicated in T Cell Regulation and Other Cellular Processes

CCR8 ( chemokine receptor CHEMR1 ) is a protein that is expressed in a variety of tissues throughout the body, including the immune system, endothelial cells, and epithelial cells. It is a member of the chemokine receptor family, which is a group of transmembrane proteins that play a critical role in the regulation of cellular responses to various signaling pathways, including the T cell response to cytokines.

CCR8 is a G protein-coupled receptor ( GPCR ), which means that it is a transmembrane protein that is associated with intracellular signaling. It is composed of an extracellular portion, a transmembrane region, and an intracellular portion. The extracellular portion of CCR8 consists of a single domain that is responsible for the binding of chemokines, while the transmembrane region consists of two transmembrane spans. The intracellular portion of CCR8 consists of a single protein that is responsible for the signaling of the receptor.

CCR8 is involved in a variety of cellular processes that are important for both the immune system and the development of various diseases. One of the main functions of CCR8 is its role in the regulation of T cell responses. T cells are a type of immune cell that play a critical role in the regulation of immunity and the immune response to infections. CCR8 is involved in the regulation of T cell proliferation, differentiation, and selection, as well as the regulation of T cell cytokine production.

In addition to its role in T cell regulation, CCR8 is also involved in the regulation of inflammation and fibrosis. CCR8 is involved in the regulation of the production and activation of pro-inflammatory cytokines, as well as the regulation of the production of anti-inflammatory cytokines. This is important for the regulation of various diseases, including cancer, autoimmune diseases, and chronic obstructive pulmonary disease ( COPD ).

CCR8 is also involved in the regulation of stem cell proliferation and differentiation. Stem cells are a type of cell that have the ability to develop into any type of cell in the body, and they play a critical role in the development and treatment of various diseases. CCR8 is involved in the regulation of stem cell proliferation and differentiation, which is important for the development of cancer, neural tube defects, and other diseases.

CCR8 is also involved in the regulation of tissue repair and regeneration. Tissue repair and regeneration are important processes that are essential for the maintenance of tissues and organs, and they are regulated by a variety of signaling pathways. CCR8 is involved in the regulation of tissue repair and regeneration, which is important for the development and maintenance of tissues and organs.

In conclusion, CCR8 is a protein that is involved in a variety of cellular processes that are important for both the immune system and the development of various diseases. Its involvement in T cell regulation, inflammation, fibrosis, stem cell proliferation and differentiation, and tissue repair and regeneration makes it an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of CCR8 in these processes and to develop effective therapies that target this protein.

Protein Name: C-C Motif Chemokine Receptor 8

Functions: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection

More Common Targets

CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7