Target Name: CCP110
NCBI ID: G9738
Other Name(s): Centriolar coiled-coil protein 110kDa | CP110 | Centrosomal protein CP110 | centrosomal protein CP110 | Cep110 | Centriolar coiled-coil protein 110, transcript variant 4 | KIAA0419 | centriolar coiled-coil protein of 110 kDa | Centrosomal protein of 110 kDa | Centriolar coiled-coil protein of 110 kDa | centriolar coiled-coil protein 110 | Centriolar coiled-coil protein 110, transcript variant 1 | CCP110 variant 4 | centriolar coiled-coil protein 110kDa | CCP110 variant 1 | centrosomal protein of 110 kDa | Centriolar coiled-coil protein of 110 kDa (isoform 1) | Centriolar coiled-coil protein of 110 kDa (isoform 2) | CP110_HUMAN

CCP110: A Protein for Small Molecules and Antibodies in Cancer and Neurodegenerative Diseases

CCP110, also known as Centriolar coiled-coil protein 110kDa, is a protein that is expressed in most tissues of the body and plays a critical role in the development and maintenance of normal cellular function. The protein is composed of 110 amino acid residues and has a calculated molecular weight of 11.3 kDa. It is localized to the endoplasmic reticulum (ER) and is involved in various cellular processes, including cell signaling, cytoskeletal organization, and protein transport.

Recent studies have identified CCP110 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its unique structure and subcellular localization make it an attractive target for small molecules and antibodies that can modulate its activity and expression levels.

One of the key features of CCP110 is its ability to form a stable coiled-coil structure in the ER. This structure is composed of two distinct regions: an N-terminal region that contains a helix and a alpha-helicle domain, and a C-terminal region that contains a parallel beta-sheet and a calbindin domain. The N-terminal region is responsible for the protein's ability to form a stable coiled-coil structure, while the C-terminal region is involved in the protein's stability and localization to the ER.

The coiled-coil structure of CCP110 has been shown to play a critical role in its function. When the protein is expressed and processed in the ER, it forms a stable coiled-coil structure that is involved in the regulation of various cellular processes, including protein transport and localization, cell signaling, and cytoskeletal organization.

In addition to its role in cellular processes, CCP110 has also been shown to play a critical role in the development and progression of various diseases. Its expression has been observed in a wide range of cancer types, including breast, ovarian, and prostate cancers. Studies have also shown that CCP110 is involved in the development of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, and that its expression is increased in individuals with certain genetic mutations that are associated with these conditions.

The unique structure and subcellular localization of CCP110 make it an attractive target for small molecules and antibodies that can modulate its activity and expression levels. Several studies have shown that CCP110 can be effectively targeted with small molecules, such as taxol and tirapazam, and that these treatments have the potential to be effective in treating various diseases. In addition, CCP110 has also been shown to be a good biomarker for several diseases, including cancer and neurodegenerative diseases.

In conclusion, CCP110 is a protein that is expressed in most tissues of the body and plays a critical role in the development and maintenance of normal cellular function. Its unique structure and subcellular localization make it an attractive target for small molecules and antibodies that can modulate its activity and expression levels. Several studies have shown that CCP110 can be effectively targeted with small molecules and that these treatments have the potential to be effective in treating various diseases. Further research is needed to fully understand the role of CCP110 in cellular processes and its potential as a drug target and biomarker.

Protein Name: Centriolar Coiled-coil Protein 110

Functions: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:17681131, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425)

More Common Targets

CCPG1 | CCR1 | CCR10 | CCR12P | CCR2 | CCR3 | CCR4 | CCR4-NOT transcription complex | CCR5 | CCR5AS | CCR6 | CCR7 | CCR8 | CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47