Target Name: CCR7
NCBI ID: G1236
Other Name(s): Epstein-Barr virus-induced G-protein coupled receptor 1 | Epstein-Barr virus induced gene 1 | CCR-7 | C-C motif chemokine receptor 7, transcript variant 1 | Bukitt's lymphoma receptor 2 | EBI1 | CC ch

CCR7: A G-Protein-Coupled Receptor for Epstein-Barr Virus-Induced G Protein-Coupled Signaling

Introduction

Epstein-Barr virus (EBV) is a member of the herpesviridae family and is highly relevant to human health due to its persistent and potentially life-threatening impact on the immune system. EBV infections are estimated to affect 60% of the population, and their Prevalence increases significantly with age, reflecting the immune system's decline over time. EBV infection is characterized by the production of latent viral particles (LVPs) in the cells, which can reactivate and cause reactivation of the virus. Chronic latency can lead to the development of Opportunistic tumors include nasal cancer, oral cancer, skin cancer and Hodgkin lymphoma.

G-Protein-Coupled Receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. They are potential drug targets and biomarkers due to their unique structural features and the ability to modulate cellular signaling pathways.

In this article, we discuss CCR7, a GPCR that is expressed in various tissues and cells and is involved in EBV infection. We review the current understanding of CCR7 function and its potential as a drug target or biomarker.

Function and Interaction of CCR7

CCR7 is a 22-kDa protein that is expressed in various tissues and cells, including spleen, lung, brain, and cervical lymphoid tissue. It is a member of the GPCR family and is characterized by the presence of a transmembrane domain, a catalytic domain , and an extracellular region (ECD).

The catalytic domain of CCR7 contains a catalytic center that is responsible for the GPCR-mediated signaling. This domain is known as the p120 subdomain and is a common structural feature in GPCRs. The p120 subdomain plays a crucial role in the regulation of intracellular signaling pathways , including the cAMP/cGMP signaling pathway.

The ECD of CCR7 contains a series of highly conserved domains, including a nucleotide-binding oligomerization domain (NBO), a leucine-rich repeat (LRR), and a calcitonin-like peptide (CIP). The NBO is a nucleotide-binding domain that is known for its role in nucleotide signaling and is involved in the regulation of various cellular processes, including cell growth, differentiation, and infection. The LRR and CIP domains are evolutionarily conserved and are involved in the regulation of intracellular signaling pathways, including the regulation of cytoskeletal organization, cell adhesion, and signaling pathways.

CCR7 has been shown to play a crucial role in the regulation of EBV infection. EBV infections are characterized by the production of latent viral particles (LVPs), which can reactivate and cause reactivation of the virus. Latency is a critical aspect of EBV infection, as it allows the virus to evade the host immune system and maintain a persistent infection.

Studies have shown that CCR7 is involved in the regulation of EBV latency. CCR7 has been shown to play a role in the regulation of the cytoskeleton organization and the maintenance of cell-cell adhesion, which are critical aspects of EBV latency. CCR7 has also been shown to be involved in the regulation of the production of EBV LVPs, which are essential for the reactivation of the virus.

Potential Drug Targets and Biomarkers

The GPCR family is a

Protein Name: C-C Motif Chemokine Receptor 7

Functions: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions

More Common Targets

CCR8 | CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69