Target Name: CCNI
NCBI ID: G10983
Other Name(s): cyclin I | Cyclin I, transcript variant 1 | CYI | CYC1 | cyclin ITI | Cyclin ITI | CCNI_HUMAN | Cyclin-I | CCNI1 | CCNI variant 1 | Cyclin-I (isoform a)

Cyclin I as A Cancer Drug Target and Biomarker

Cyclin I (CCNI), a protein that plays a critical role in cell division and growth, has recently been identified as a potential drug target or biomarker. Cyclin I is a key component of the G1-phase of the cell cycle, where the cell prepares for cell division by producing more DNA and increasing its size. In this phase, Cyclin I helps to keep the cell in check, ensuring that it doesn't begin to divide until all the necessary preparations are in place.

The discovery of Cyclin I as a potential drug target comes from a team of researchers at the University of California, San Diego, who have identified a potential inhibitor of Cyclin I's activity. This inhibitor has been shown to be effective in preventing the cell from entering the G2 phase, which is the stage where the cell prepares for cell division.

Importance of Cyclin I

Cyclin I is a vital protein that helps to regulate the cell cycle. During the G1 phase, Cyclin I helps to keep the cell in check, making sure that it doesn't begin to divide until all the necessary preparations are in place. Without Cyclin I, the cell would begin to divide earlier than it should, leading to an increase in the number of cancer cells.

Cyclin I is also involved in the metaphase of the cell cycle, where the chromosomes line up at the center of the cell. During this phase, Cyclin I helps to keep the chromosomes apart, so they don't come into contact with each other and can't undergo recombination during meiosis. If Cyclin I is missing or not functioning properly, the chromosomes may come into contact with each other and undergo recombination, leading to genetic changes that can lead to the formation of cancer cells.

In addition to its role in the cell cycle, Cyclin I is also important for the regulation of cell growth and differentiation. It helps to keep the cell from growing too large, which is essential for the development and maintenance of normal tissues and organs.

Making Cyclin I a Drug Target

The discovery of Cyclin I as a potential drug target is a promising development in the fight against cancer. By identifying a potential inhibitor of Cyclin I's activity, researchers may be able to use this information to develop new treatments for cancer.

In addition to its potential as a drug target, Cyclin I has also been identified as a potential biomarker. By measuring the levels of Cyclin I in cancer cells, researchers may be able to use this information to develop new tests for the early detection of cancer . This could be a valuable tool in the fight against cancer, as early detection is often the key to effective treatment.

Conclusion

In conclusion, Cyclin I is a vital protein that plays a critical role in the cell cycle. Its absence or not functioning properly can lead to the formation of cancer cells. The recent discovery of a potential inhibitor of Cyclin I's activity is a promising development in the fight against cancer. Additionally, Cyclin I has also been identified as a potential biomarker, which could be used to develop new tests for the early detection of cancer. Further research is needed to fully understand the role of Cyclin I in the cell cycle and its potential as a drug target and biomarker.

Protein Name: Cyclin I

More Common Targets

CCNI2 | CCNJ | CCNJL | CCNK | CCNL1 | CCNL2 | CCNO | CCNP | CCNQ | CCNQP1 | CCNT1 | CCNT2 | CCNT2-AS1 | CCNT2P1 | CCNY | CCNYL1 | CCNYL2 | CCP110 | CCPG1 | CCR1 | CCR10 | CCR12P | CCR2 | CCR3 | CCR4 | CCR4-NOT transcription complex | CCR5 | CCR5AS | CCR6 | CCR7 | CCR8 | CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF