CCL23: A Potential Drug Target Or Biomarker (G6368)

Target Name: CCL23

NCBI ID: G6368

CCL23: A Potential Drug Target Or Biomarker

CCL23 (Macrophage Inflammatory Protein 3) is a protein that is expressed in the cells of the immune system, including macrophages. It is a pro-inflammatory protein that is involved in the recruitment of immune cells to sites of infection or tissue damage. CCL23 is a potential drug target or biomarker in the treatment of a variety of diseases, including cancer, inflammation, and autoimmune disorders.

CCL23 is a 23-kDa protein that is expressed in a variety of tissues, including the brain, spleen, heart, lungs, and lymphoid organs. It is mainly expressed by macrophages and is a key molecule in the inflammatory response. During an inflammatory response, CCL23 attracts immune cells to sites of inflammation by binding to receptors on their surfaces, such as PD-1. This helps activate the immune response to clear the pathogen.

However, the expression level of CCL23 is also involved in the occurrence and development of various diseases. For example, in tumorigenesis, CCL23 expression levels increase as tumors grow. Additionally, CCL23 levels are elevated in inflammatory diseases such as rheumatoid arthritis and autoimmune diseases. Therefore, CCL23 can serve as a potential therapeutic target for these diseases.

The biological functions of CCL23 also indicate that it may be related to the occurrence and development of certain diseases. For example, research has shown that CCL23 is associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In these diseases, nerve cells are damaged by inflammation, leading to neuronal death and degeneration. Therefore, CCL23 may be involved in the onset and progression of neurodegenerative diseases.

In addition, CCL23 is also related to the function of immune cells. Research shows that CCL23 can promote the activation and proliferation of immune cells. This helps strengthen the immune system to eliminate pathogens. Therefore, CCL23 plays an important role in the immune system.

The biological function and expression level of CCL23 are related to the occurrence and development of various diseases. Therefore, CCL23 may be a potential drug target or biomarker. Studying the biological function and expression level of CCL23 will help to better understand the inflammatory response and the function of the immune system, and provide new ideas and methods for the treatment of various diseases.

Protein Name: C-C Motif Chemokine Ligand 23

Functions: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23

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