TAS2R13: A Potential Drug Target and Biomarker for Taste and smell

Target Name: TAS2R13

NCBI ID: G50838

TAS2R13: A Potential Drug Target and Biomarker for Taste and smell

Introduction

Taste and smell are essential functions in our daily life, but their complex mechanisms are not fully understood. The TAS2R13 gene, located on chromosome 7p11.1, is a key regulator of taste and smell perception in the mouse. Mutations in the TAS2R13 gene have has been linked to various taste and smell disorders, including polyposis nigricans and syndrome dextroscrotal hyperplasia (SDH). The identification of TAS2R13 as a potential drug target and biomarker provides new insights into the molecular mechanisms underlying taste and smell perception.

Background

Taste and smell are complex sensory experiences that rely on the intricate interplay of multiple brain regions and neurotransmitters. The sense of taste is primarily mediated by the tongue, while the sense of smell is primarily mediated by the nose. The TAS2R13 gene is a key regulator of taste and smell perception in the mouse. Mutations in the TAS2R13 gene have been linked to various taste and smell disorders, including polyposis nigricans (PN) and syndrome dextroscrotal hyperplasia (SDH).

TAS2R13 function

The TAS2R13 gene encodes a transmembrane protein that belongs to the TAS family of G protein-coupled receptors (GPCRs). GPCRs are a diverse family of membrane proteins that play a central role in sensory perception, including taste and smell. The TAS2R13 protein is composed of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain contains a N-terminal伪-helices and a C-terminal GPCR-specific 伪-helix, while the transmembrane region contains a putative transmembranespanning region (TMSR) and a variable region (V1).

In taste perception, TAS2R13 is expressed in the taste buds of the tongue and is involved in the perception of sweet, sour, and umami flavors. The TAS2R13 protein is also involved in the regulation of taste texture, which refers to the sensation of soft, hard, or slipperyness of the taste.

In smell perception, TAS2R13 is expressed in the dendrites of sensory neurons and is involved in the perception of volatile organic compounds (VOCs), such as odors. The TAS2R13 protein is also involved in the regulation of smell intensity, which refers to the intensity of the smell sensation.

Diseases associated with TAS2R13 mutations

Mutations in the TAS2R13 gene have been linked to various taste and smell disorders. The most well-known disorder associated with TAS2R13 mutations is polyposis nigricans (PN), a rare genetic disorder characterized by the development of skin tags (seborrheic keratoses) and other skin -related lesions. PN is caused by mutations in the TAS2R13 gene, which result in the production of an aberrant protein that is involved in the development of skin tags.

In addition to PN, TAS2R13 mutations have also been linked to other taste and smell disorders, including syndrome dextroscrotal hyperplasia (SDH) and Shibing syndrome (ASD).

TAS2R13 as a drug target

The identification of TAS2R13 as a potential drug target provides new insights into the molecular mechanisms underlying taste and smell perception. The TAS2R13 protein is involved in the regulation of both taste and smell perception, making it an attractive target for small molecule inhibitors. Several studies have shown that TAS2R13 is a validated drug target, and several compounds have been shown to be effective in

Protein Name: Taste 2 Receptor Member 13

Functions: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

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