TLR7: Key Regulator of Innate Immune System (G51284)

Target Name: TLR7

NCBI ID: G51284

TLR7: Key Regulator of Innate Immune System

TLR7 (TLR7_HUMAN) is a protein that is expressed in many different tissues throughout the body. It is a key regulator of the innate immune system, which is responsible for protecting the body against infection and other harmful substances. TLR7 is composed of two subunits, TLR7A and TLR7B, which are located on the surface of many different cell types in the body.

The TLR7 system is involved in a wide range of physiological processes in the body, including the regulation of inflammation, cell death, and cell proliferation. TLR7 is activated in response to the presence of certain stressors, such as bacteria, viruses, and other pathogens, as well as in response to certain types of damage or stress, such as physical exercise or exposure to certain chemicals.

TLR7 is a potential drug target because of its involvement in a variety of important biological processes. For example, TLR7 has been shown to play a role in the regulation of inflammation, which is a major contributor to many diseases, including heart disease, diabetes, and cancer. TLR7 has also been shown to be involved in the regulation of cell death, which is important for the proper functioning of many different cell types in the body.

In addition to its potential role in disease, TLR7 is also a valuable biomarker for a variety of applications. For example, TLR7 has been shown to be expressed in a variety of different cell types in the body, including immune cells, endothelial cells, and epithelial cells. This makes it a potential target for diagnostic tests that are designed to detect the expression of TLR7 in these cells. Additionally, TLR7 has been shown to be involved in the regulation of cellular signaling pathways, which is important for the function of many different cell types in the body. This makes it a potential target for drugs that are designed to modulate these signaling pathways.

TLR7 is also a potential target for research into the role of the innate immune system in human disease. The innate immune system is a complex system that is responsible for protecting the body against a wide range of threats, including pathogens, toxins, and other harmful substances. TLR7 is a key regulator of this system, and its function is likely to be important for the proper functioning of the immune system.

Overall, TLR7 is a protein that is involved in a wide range of important biological processes in the body. Its potential as a drug target and biomarker make it an attractive target for research in the fields of medicine and biotechnology.

Protein Name: Toll Like Receptor 7

Functions: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371)

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