TMEM106B: A Drug Target / Disease Biomarker (G54664)

Target Name: TMEM106B

NCBI ID: G54664

TMEM106B: A Drug Target / Disease Biomarker

TMEM106B, also known as heat shock protein 90 (Hsp90), is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, lungs, and kidneys. It is a heat shock protein, which means that it is produced in response to an increase in temperature, such as that caused by exercise or inflammation.

Hsp90 is a protein that is involved in a number of different processes in the body, including the regulation of cell death, inflammation, and stress. It is also involved in the development and maintenance of the blood-brain barrier, which is a barrier that separates the brain from the surrounding blood and helps to protect it from harmful substances.

One of the things that makes Hsp90 such an interesting drug target is its ability to interact with a variety of different molecules. This makes it a potentially promising target for a range of different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the ways that Hsp90 interacts with other molecules is through its ability to form complexes with other proteins. These complexes can be either positive or negative, depending on the other protein with which they are associated. Hsp90 can form negative complexes with other proteins that are involved in stress response, such as transcription factors, and positive complexes with proteins that are involved in inflammation.

Another way that Hsp90 interacts with other molecules is through its ability to modulate the activity of other proteins. This is done through a process called phosphorylation, which involves the addition of a phosphate group to a specific amino acid. Hsp90 can modulate the activity of other proteins by adding or removing phosphate groups from their amino acids.

One of the things that makes Hsp90 such an interesting drug target is its ability to interact with a variety of different molecules. This makes it a potentially promising target for a range of different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its ability to interact with other proteins, Hsp90 is also involved in a number of different signaling pathways. For example, it is involved in the regulation of the cell cycle, and in the production of reactive oxygen species (ROS), which can damage cells and contribute to a variety of different diseases, including cancer.

Another way that Hsp90 is involved in signaling pathways is through its role in the production of heat shock proteins (HSPs). HSPs are proteins that are produced in response to an increase in temperature, such as that caused by exercise or inflammation. Hsp90 is one of the best-known HSPs, and it is involved in the regulation of the production and degradation of other HSPs.

Hsp90 is also involved in the regulation of a variety of different cellular processes, including the production of new blood vessels, the regulation of ion channels, and the production of neurotransmitters. It is also involved in the regulation of the immune system, and in the development and maintenance of the blood-brain barrier.

In conclusion, TMEM106B, also known as Hsp90, is a protein that is expressed in a variety of tissues throughout the body, and it is involved in a number of different processes in the body, including the regulation of cell death, inflammation, stress, the cell cycle, and signaling pathways. Its ability to interact with a variety of different molecules makes it a potentially promising drug target for a range of different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of Hsp90 in the body and its potential as a drug target.

Protein Name: Transmembrane Protein 106B

Functions: In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity)

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