TMEM129: A Protein Target for Drug Research (G92305)

Target Name: TMEM129

NCBI ID: G92305

TMEM129: A Protein Target for Drug Research

TMEM129 (TM129_HUMAN), also known as heat shock protein 70 (HSP70), is a protein that is expressed in a variety of tissues throughout the body. It is a member of the HSP70 family, which is known for their ability to withstand and recover from temperatures, including those that are above 100 degrees Fahrenheit. TMEM129 is expressed in a wide range of tissues, including the heart, lungs, kidneys, and brain, and has been shown to play a role in a number of physiological processes.

One of the things that makes TMEM129 such an interesting drug target is its unique structure. TMEM129 is a type of protein that is made up of multiple domains, including an N-terminal domain, a C-terminal domain, and a middle domain. The middle domain is the largest and is responsible for the protein's unique structure and function. This domain is made up of a series of coiled regions that are able to form a stable structure when the protein is heated, allowing it to withstand high temperatures.

TMEM129 has been shown to play a role in a number of physiological processes, including the regulation of inflammation, the immune response, and the transport of oxygen and nutrients to tissues. For example, studies have shown that TMEM129 is expressed in the lungs and is involved in the regulation of surfactant production, which is important for the proper functioning of the lungs.

In addition to its role in physiological processes, TMEM129 has also been shown to be a potential drug target. Its unique structure and the fact that it is expressed in a wide range of tissues make it an attractive target for researchers to study. Additionally, TMEM129 has been shown to interact with a number of different molecules, including transcription factors and signaling proteins, which makes it a potential target for a variety of different drugs.

One of the challenges in studying TMEM129 as a drug target is its complex structure. Because it is made up of multiple domains, it is difficult to study and understand all of the different mechanisms that are involved in its function. However, researchers are making progress in understanding how TMEM129 functions and how it can be targeted by drugs.

In conclusion, TMEM129 is a protein that is expressed in a variety of tissues throughout the body and is known for its unique structure and ability to withstand high temperatures. Its role in physiological processes makes it an attractive target for drug research, and its complex structure makes it difficult to study. Further research is needed to fully understand TMEM129's function and its potential as a drug target.

Protein Name: Transmembrane Protein 129, E3 Ubiquitin Ligase

Functions: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation

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