TMEM174: A Transmembrane Protein for Drug Targets and Biomarkers

Target Name: TMEM174

NCBI ID: G134288

Other Name(s): Transmembrane protein 174 | TM174_HUMAN | transmembrane protein 174

TMEM174: A Transmembrane Protein for Drug Targets and Biomarkers

TMEM174 (Transmembrane protein 174) is a gene that encodes a protein located at the cell membrane that plays a crucial role in various cellular processes. TMEM174 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Importance of TMEM174

TMEM174 is a transmembrane protein, which means that it spans the cell membrane and interacts with both the cytoplasm and the cell surface. It is involved in various cellular processes, including signal transduction, intracellular signaling, and cell adhesion. TMEM174 plays a key role in regulating the formation and stability of tight junctions, which are a type of cell-cell adhesion that helps maintain tissue structure and function.

TMEM174 has been shown to be involved in various signaling pathways, including the TGF-β pathway, which plays a crucial role in cell growth, differentiation, and survival. The TGF-β pathway is a well-established target for many diseases, including cancer, and TMEM174 has been shown to be involved in the regulation of TGF-β signaling in various cellular contexts.

In addition to its role in TGF-β signaling, TMEM174 has also been shown to be involved in the regulation of other signaling pathways, including the PI3K/AKT signaling pathway, which is involved in cell survival and metabolism, and the NF-kappa-B signaling pathway, which is involved in inflammation and stress responses.

The Potential of TMEM174 as a Drug Target

TMEM174 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with the development and progression of many diseases. For example, TMEM174 has been shown to be involved in the regulation of TGF-β signaling, which is often disrupted in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its involvement in TGF-β signaling, TMEM174 has also been shown to be involved in the regulation of other signaling pathways, including PI3K/AKT and NF-kappa-B signaling. This suggests that TMEM174 may be a useful target for drugs that target these signaling pathways.

The Potential of TMEM174 as a Biomarker

TMEM174 has also been identified as a potential biomarker for various diseases. Its involvement in various cellular processes that are associated with the development and progression of many diseases makes it an attractive candidate for use as a biomarker.

For example, TMEM174 has been shown to be involved in the regulation of TGF-β signaling, which is often disrupted in many diseases, including cancer. This suggests that TMEM174 may be a useful biomarker for assessing the effectiveness of drugs that target TGF-β signaling.

In addition to its involvement in TGF-β signaling, TMEM174 has also been shown to be involved in the regulation of other signaling pathways, including PI3K/AKT and NF-kappa-B signaling. This suggests that TMEM174 may be a useful biomarker for assessing the effects of drugs that target these signaling pathways.

Conclusion

TMEM174 is a transmembrane protein that has been shown to be involved in various cellular processes that are associated with the development and progression of many diseases. Its potential as a drug target and biomarker makes it an attractive candidate for further research. Further studies are needed to determine the full role of TMEM174 in cellular processes and its potential as a drug

Protein Name: Transmembrane Protein 174

Functions: Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney

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