TMEM139-AS1: A Potential Drug Target and Biomarker (G105375545)

Target Name: TMEM139-AS1

NCBI ID: G105375545

Other Name(s): TMEM139 antisense RNA 1

TMEM139-AS1: A Potential Drug Target and Biomarker

TMEM139-AS1, also known as TMEM139 antisense RNA 1, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is derived from the transmembrane protein TMEM139 and is expressed in various tissues and cell types, including the brain, heart, and pancreas. The unique feature of TMEM139-AS1 is its ability to interact with small molecules, such as drugs, leading to the potential for it to be used as a drug target or biomarker.

TMEM139-AS1 is a 24.1 kilobase (kb) RNA molecule and has a unique 5'-end that contains a unique nucleotide sequence of GCTCACTG. It is expressed in various tissues and cell types and has been shown to play a role in various physiological processes , including cell signaling, protein synthesis, and inflammation.

One of the unique aspects of TMEM139-AS1 is its ability to interact with small molecules, such as drugs. This interaction has led to the potential for TMEM139-AS1 to be used as a drug target or biomarker. TMEM139-AS1 has been shown to interact with a variety of small molecules, including inhibitors of the protein kinase kinase A (PKA) and tyrosine kinase inhibitors. These interactions may lead to changes in the expression and activity of TMEM139-AS1, potentially providing insight into its role in various physiological processes.

In addition to its potential as a drug target, TMEM139-AS1 also has the potential as a biomarker. Its expression has been shown to be regulated by various factors, including gene expression, RNA processing, and protein translation. This regulation may provide insight into the mechanisms underlying its expression and potential as a biomarker.

TMEM139-AS1 has also been shown to play a role in various diseases, including cancer and neurodegenerative diseases. For example, studies have shown that TMEM139-AS1 is overexpressed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. This overexpression has been associated with the development of neurodegeneration and the loss of TMEM139-AS1 function.

In conclusion, TMEM139-AS1 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its unique ability to interact with small molecules and its regulation by various factors make it an attractive candidate for further investigation. Further studies are needed to fully understand its role in various physiological processes and its potential as a drug target or biomarker.

Protein Name: TMEM139 Antisense RNA 1

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