TMEM138: A Promising Drug Target Or Biomarker (G51524)

Target Name: TMEM138

NCBI ID: G51524

TMEM138: A Promising Drug Target Or Biomarker

TMEM138 (TM138_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is a member of the transmembrane protein family, which means that it spans the cell membrane and functions as a protein that connects different parts of the cell.

TMEM138 has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and location in the body make it an attractive target for drug developers because it is difficult to reach with small molecules.

One of the reasons that TMEM138 is a promising drug target is its location in the brain. The brain is a particularly difficult organ to target with drugs because it is surrounded by a protective barrier called the blood-brain barrier. The blood-brain barrier is designed to protect the brain from harmful substances, but it also makes it difficult for drugs to reach the brain.

However, TMEM138 is thought to be able to bypass this barrier because it is part of a family of proteins called transmembrane proteases, which are known for their ability to break down the blood-brain barrier. This could giveTMEM138 an advantage over other drugs that are limited to traveling through the blood-brain barrier.

Another reason why TMEM138 is a promising drug target is its role in various diseases. For example, TMEM138 has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. It has also been shown to be involved in the development of certain types of cancer, such as melanoma and breast cancer.

In addition to its potential role in disease, TMEM138 is also thought to be a valuable biomarker for tracking disease progression. Its expression has been shown to be elevated in the brains of people with certain types of cancer, which could be used as a marker for disease progression. This could make TMEM138 an attractive target for drugs that are designed to slow down or stop the progression of cancer.

Overall, TMEM138 is a protein that is located in an important organ and is involved in a variety of diseases. Its unique structure and location make it an attractive target for drug developers. Further research is needed to fully understand its role in the body and its potential as a drug target or biomarker.

Protein Name: Transmembrane Protein 138

Functions: Required for ciliogenesis

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