MOV10L1: A Drug Target / Disease Biomarker (G54456)

Target Name: MOV10L1

NCBI ID: G54456

MOV10L1: A Drug Target / Disease Biomarker

MOV10L1, also known as MOV10L1A, is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the moving protein family, which includes proteins that play a critical role in intracellular trafficking and the delivery of cellular signaling molecules.

MOV10L1 is characterized by its unique structure and localization. It consists of a 152-amino acid protein with a calculated molecular mass of 19.9 kDa. The protein has a unique N-terminus that is rich in positively charged amino acids, which is known as an electrostatic site. This site is important for the protein's ability to interact with other proteins and for its role in intracellular signaling.

One of the unique features of MOV10L1 is its ability to form a stable complex with the protein p120GAP, which is a key regulator of protein-protein interactions in the cell. This complex plays a critical role in the regulation of cellular processes such as cell division, apoptosis, and signaling pathways.

MOV10L1 has also been shown to play a role in the regulation of inflammation and immune responses. Studies have shown that MOV10L1 is involved in the regulation of the expression of immune response genes, such as those that produce antibodies against foreign substances like viruses and bacteria.

In addition to its role in intracellular signaling and immune regulation, MOV10L1 has also been shown to play a critical role in the development and progression of various diseases, including cancer. Studies have shown that MOV10L1 is involved in the regulation of cell cycle progression, which is a critical factor in the development of cancer.

MOV10L1 has also been shown to be involved in the regulation of cell migration and the development of tissues, such as the skin and heart. This protein has been shown to play a critical role in the regulation of cell-cell adhesion and the formation of tissues during development.

In conclusion, MOV10L1 is a protein that has a unique structure and localization and is involved in a wide range of cellular processes in the body. Its role in intracellular signaling, immune regulation, and cancer development makes it an attractive target for drug development. Further research is needed to fully understand the mechanisms of MOV10L1's function in the body and its potential as a drug.

Protein Name: Mov10 Like RISC Complex RNA Helicase 1

Functions: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins

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