Target Name: NUP133
NCBI ID: G55746
Other Name(s): nucleoporin 133kDa | NPHS18 | 133 kDa nucleoporin | Nuclear pore complex protein Nup133 | nucleoporin 133kD | Nucleoporin 133 | GAMOS8 | NU133_HUMAN | Nucleoporin 133kD | nucleoporin Nup133 | nucleoporin 133 | Nucleoporin Nup133 | hNUP133

NUP133: A Potential Drug Target and Biomarker

Nucleoporin 133kDa (NUP133) is a protein that is expressed in various cell types, including neurons, muscle cells, and cancer cells. Its primary function is to regulate the movement of ions and molecules into and out of cells. It is a small molecule that can interact with various nuclear proteins, leading to its name. NUP133 has been identified as a potential drug target and biomarker due to its unique structure and its involvement in various cellular processes.

The protein NUP133 is composed of 133 amino acid residues and has a calculated molecular weight of 14.9 kDa. It has a characteristic Rossmann-fold, which is a type of alpha-helices, and a unique 尾-sheet that is composed of three beta-helices. This 尾-sheet is the site of the protein's stability and plays a crucial role in its stability and interactions with other proteins.

NUP133 has been shown to have various functions in various cellular processes. One of its most significant functions is its role in intracellular signaling. NUP133 has been shown to play a role in the regulation of ion channels, which are responsible for the movement of nutrients, ions, and other molecules into and out of cells. It has been shown to interact with various ion channels, including the Na+/K+-ATPase, which is responsible for regulating the movement of nutrients into and out of cells.

In addition to its role in intracellular signaling, NUP133 has also been shown to have a role in the regulation of cell adhesion. It has been shown to interact with the protein N-cadherin, which is responsible for the formation of tight junctions between cells. This interaction between NUP133 and N-cadherin suggests that NUP133 may be involved in the regulation of cell-cell adhesion.

NUP133 has also been shown to have a role in the regulation of cell cycle progression. It has been shown to interact with the protein p21, which is a transcription factor that is involved in the regulation of cell cycle progression. This interaction between NUP133 and p21 suggests that NUP133 may be involved in the regulation of cell cycle progression.

In addition to its role in intracellular signaling, NUP133 has also been shown to have a role in the regulation of protein stability. It has been shown to interact with the protein HIPK3, which is involved in the regulation of protein stability. This interaction between NUP133 and HIPK3 suggests that NUP133 may be involved in the regulation of protein stability.

Due to its unique structure and its involvement in various cellular processes, NUP133 has been identified as a potential drug target. Studies have shown that NUP133 can be inhibited by small molecules, which suggests that it may be a useful target for drug development. In addition, NUP133 has also been shown to be a biomarker for various diseases, including cancer. The detection and quantification of NUP133 in cancer cells may be a useful diagnostic tool for cancer treatment.

In conclusion, NUP133 is a protein that has various functions in various cellular processes, including intracellular signaling, cell adhesion, and cell cycle progression. Its unique structure and its involvement in these processes make it a potential drug target and biomarker. Further studies are needed to fully understand the role of NUP133 in cellular processes and its potential as a drug target and biomarker.

Protein Name: Nucleoporin 133

Functions: Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222)

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NUP153 | NUP155 | NUP160 | NUP188 | NUP205 | NUP210 | NUP210L | NUP210P1 | NUP210P2 | NUP214 | NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2 | OCLM | OCLN | OCLNP1 | OCM | OCM2 | OCRL | OCSTAMP | ODAD1 | ODAD2