SEPTIN11: A Potential Drug Target and Biomarker (G55752)

Target Name: SEPTIN11

NCBI ID: G55752

SEPTIN11: A Potential Drug Target and Biomarker

SEPTIN11, also known as Septin 11 transcript variant 2, is a protein that plays a crucial role in the organization and function of cells. It is a member of the SEPIN family, which is known for its role in the regulation of cell signaling and cytoskeletal organization. SEPTIN11 is expressed in a wide range of tissues and cells, including epithelial, mesenchymal, and neural cells. Its function is essential in the development, maintenance, and regulation of tissues and organs, including the brain and spinal cord.

SEPTIN11 has been identified as a potential drug target due to its unique structure and the processes it is involved in. The SEPIN family consists of nine proteins, including SEPTIN11, that are characterized by a conserved N-terminal region, a unique C-terminal region, and a variable middle region. The C-terminal region is known for its role in the formation of the SEPIN signature, which is a conserved motif that is present in many proteins that are involved in cytoskeletal organization and cell signaling.

SEPTIN11 is involved in the regulation of several cellular processes that are critical for tissue development and maintenance. It is involved in the development and maintenance of the neural stem cell pool, which is responsible for the production of new neurons that replace damaged or lost cells. It is also involved in the regulation of the cell cycle, which is the process by which cells grow, divide, and replicate their genetic material. In addition, SEPTIN11 is involved in the regulation of cell migration, which is the movement of cells to new locations in the body.

SEPTIN11 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its involvement in these processes makes it an attractive target for drug development. The discovery and characterization of SEPTIN11 as a potential drug target and biomarker has the potential to lead to new treatments for a variety of diseases.

In conclusion, SEPTIN11 is a protein that plays a critical role in the regulation of cell signaling and cytoskeletal organization. Its unique structure and the processes it is involved in make it an attractive target for drug development. Further research is needed to fully understand the role of SEPTIN11 in the regulation of tissues and cells, as well as its potential as a drug target and biomarker.

Protein Name: Septin 11

Functions: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy

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