METTL14: A Protein Implicated in Cellular Metabolism and Drug Targets

Target Name: METTL14

NCBI ID: G57721

METTL14: A Protein Implicated in Cellular Metabolism and Drug Targets

METTL14 (MET14_HUMAN), also known as METTL14-ASP or METTL14, is a protein that is expressed in a variety of tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the METTL family of proteins, which are known for their role in regulating mitochondrial dynamics and energy metabolism.

METTL14 is a 21-kDa protein that consists of 191 amino acid residues. It has a calculated pI of approximately 6.5 and a predicted localization in the cytoplasm. METTL14 is predominantly expressed in the brain, with a particularly strong expression in the prefrontal cortex, which is known for its role in executive function and decision-making.

METTL14 has been shown to play a role in a variety of cellular processes, including metabolism, inflammation, and autophagy. For example, METTL14 has been shown to be involved in the metabolism of fatty acids, which are critical for brain function and development. METTL14 has also been shown to be involved in the regulation of inflammation, as it has been shown to play a role in the production of pro-inflammatory cytokines.

In addition to its role in cellular processes, METTL14 has also been shown to be a potential drug target. Researchers have identified several potential drug targets for METTL14, including those that are involved in the regulation of mitochondrial dynamics and energy metabolism. For example, one potential drug target is the zlotonic acid metabolic pathway, which is a metabolic pathway that is involved in the production of long-chain fatty acids, which have been shown to be involved in a variety of cellular processes, including metabolism and inflammation.

Another potential drug target for METTL14 is the recruitment of adaptase, which is a protein that is involved in the recruitment of adapter proteins to the plasma membrane. METTL14 has been shown to play a role in the regulation of recruitment of adaptase, and it has been suggested as a potential drug target for a variety of diseases, including cancer.

In conclusion, METTL14 is a protein that has been shown to play a role in a variety of cellular processes, including metabolism, inflammation, and autophagy. It is also a potential drug target, with several potential drug targets identified for it, including those involved in the regulation of mitochondrial dynamics and energy metabolism, and the recruitment adaptase. Further research is needed to fully understand the role of METTL14 in cellular processes and its potential as a drug target.

Protein Name: Methyltransferase 14, N6-adenosine-methyltransferase Subunit

Functions: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity)

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