Target Name: RNASEL
NCBI ID: G6041
Other Name(s): RNase L | ribonuclease 4 | Ribonuclease L | RNS4 | RN5A_HUMAN | PRCA1 | Interferon-induced 2-5A-dependent RNase | 2',5'-oligoisoadenylate synthetase-dependent | HPC1 | 2-5A-dependent ribonuclease | ri

Understanding RNASEL: Potential Drug Targets for Cancer and Neurodegenerative Diseases

RNA-Nucleic Acid-Lipid (RNASEL), also known as RNase L, is a protein that is expressed in various cell types of the human body. It is a key player in the regulation of gene expression and has been implicated in a wide range of cellular processes. Despite its importance, little is known about RNASEL and its potential as a drug target or biomarker.

RNASEL is a 21-kDa protein that is expressed in various cell types of the human body, including the liver, lung, heart, kidney, and brain. It is a member of the RNA-protein subfamily and is composed of a 166 amino acid protein that consists of a catalytic domain and a non-catalytic domain. The non-catalytic domain of RNASEL contains a unique lipid sequence that is known as a lipid-rich domain.

RNASEL plays a critical role in the regulation of gene expression and has been implicated in a wide range of cellular processes. One of the most well-known functions of RNASEL is its role in DNA double-strand break repair. RNASEL is involved in the repair of double-strand breaks in DNA by catalyzing the activity of the enzyme DNA polymerase II. This role of RNASEL is important for the regulation of genome stability and for the prevention of genetic mutations.

In addition to its role in DNA double-strand break repair, RNASEL is also involved in the regulation of gene expression and has been shown to play a role in the regulation of cell adhesion. RNASEL has been shown to be involved in the regulation of cell adhesion by controlling the activity of the protein cadherin, which is a transmembrane protein that is involved in cell-cell adhesion.

RNASEL has also been shown to play a role in the regulation of cell survival and has been implicated in the regulation of cell proliferation. RNASEL has been shown to be involved in the regulation of cell proliferation by controlling the activity of the enzyme p53, which is a key regulator of DNA damage repair.

Despite its importance, RNASEL is still a relatively unstudied protein and there is limited information about its potential as a drug target or biomarker. However, recent studies have shown that RNASEL may have potential as a drug target for the treatment of various diseases.

One potential drug target for RNASEL is the treatment of cancer. RNASEL has been shown to play a role in the regulation of cell proliferation and has been implicated in the regulation of cancer cell growth. Therefore, RNASEL may be a useful target for the treatment of cancer by inhibiting its activity.

Another potential drug target for RNASEL is the treatment of neurodegenerative diseases. RNASEL has been shown to play a role in the regulation of gene expression and has been implicated in the regulation of neurodegenerative diseases. Therefore, RNASEL may be a useful target for the treatment of neurodegenerative diseases by inhibiting its activity.

In conclusion, RNASEL is a protein that is expressed in various cell types of the human body and plays a critical role in the regulation of gene expression. Its functions include DNA double-strand break repair, cell adhesion, cell survival, and cell proliferation. Despite its importance, RNASEL is still a relatively unstudied protein and has limited potential as a drug target or biomarker. Further research is needed to fully understand the role of RNASEL in the regulation of gene expression and its potential as a drug target or biomarker.

Protein Name: Ribonuclease L

Functions: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length

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RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1