Target Name: RNF145
NCBI ID: G153830
Other Name(s): RN145_HUMAN | ring finger protein 145 | RING finger protein 145 (isoform 1) | Ring finger protein 145, transcript variant 1 | RNF145 variant 1 | RING finger protein 145

RNF145: A Promising Drug Target for RNA-Nucleic Acid-Activated Pyruvate Carrier Proteins

RNA-Nucleic Acid-Activated Pyruvate Carrier Proteins (RNP) are a family of proteins that play a crucial role in various cellular processes, including metabolism, stress response, and cell signaling. One of the subfamilies of RNP proteins is the RNF145 (Regulon Analysis In the article, Regulon ID is 145) protein, which is a key regulator of the DNA damage response (DDR) pathway in eukaryotic cells.

The DDR pathway is a complex cellular process that involves the detection and repair of DNA damage caused by various stressors, such as ionizing radiation, UV radiation, and chemical agents. The DDR pathway is activated when damage to DNA is detected, and the proteins involved in this process work together to ensure that the damage is repaired efficiently and accurately.

RNF145 is a key regulator of the DDR pathway, as it plays a role in the formation of the DNA damage complex (DDC), which is the first step in the DDR pathway. The DDC is a protein complex composed of several different proteins that work together to ensure the detection and repair of DNA damage.

In addition to its role in the DDR pathway, RNF145 has also been shown to be involved in a variety of other cellular processes. For example, it has been shown to play a role in cell signaling, as well as in the regulation of cell cycle progression and apoptosis.

Due to the potential role of RNF145 in drug research and biomarker research, scientists have conducted in-depth research on it and discovered many biological processes related to the occurrence and development of diseases. These studies provide an important theoretical basis for a deep understanding of the biological processes of RNA-Nucleic Acid-Activated Pyruvate Carrier Proteins (RNP) and provide important clues for the development of new treatments and biomarkers.

Pharmacological research on RNF145 has entered the preclinical stage. The research focus is to determine the effectiveness of RNF145 as a drug target and evaluate its safety and pharmacokinetics. In addition, scientists are studying RNF145's biomarker potential to assess drug effectiveness and dosage by monitoring biomarker levels in patients.

Overall, RNF145 is a very promising drug target with high therapeutic potential. Through further research, scientists will reveal more biological processes of RNA-Nucleic Acid-Activated Pyruvate Carrier Proteins (RNP) in drug research and biomarker research, providing important theories for the development of new treatments and biomarkers. Base.

Protein Name: Ring Finger Protein 145

Functions: E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis

More Common Targets

RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1 | RNFT2 | RNGTT | RNH1 | RNLS | RNMT | RNPC3 | RNPC3-DT | RNPEP | RNPEPL1 | RNPS1 | RNPS1P1 | RNR1 | RNR2 | RNU1-1 | RNU1-100P | RNU1-108P | RNU1-11P | RNU1-134P | RNU1-18P | RNU1-3 | RNU1-31P | RNU1-32P | RNU1-36P | RNU1-38P | RNU1-4 | RNU1-42P | RNU1-55P | RNU1-61P | RNU1-63P | RNU1-72P | RNU1-73P | RNU1-78P | RNU1-7P | RNU1-82P