RPS6KB2: A promising drug target for treating cancer and other diseases

Target Name: RPS6KB2

NCBI ID: G6199

RPS6KB2: A promising drug target for treating cancer and other diseases

Ribosomal protein S6 kinase (RPS6KB2) is a protein that plays a critical role in cell biology, particularly in the regulation of gene expression and translation. It is a 70kDa polypeptide that is expressed in various cell types and is involved in the process of translation of mRNAs into proteins. RPS6KB2 has been identified as a potential drug target and a biomarker for various diseases, including cancer. In this article, we will discuss the biology of RPS6KB2, its potential as a drug target, and its potential as a biomarker for cancer and other diseases.

Biogenesis and function

RPS6KB2 is a member of the RPS6K family of proteins, which are involved in the regulation of gene expression and translation. These proteins are characterized by a specific domain that includes a catalytic active site and a nucleotide-binding site. RPS6KB2 contains a unique N-terminal region that includes a 25 amino acid long terminal extension, which is known as the N-terminal hypervariable region (HVR).

RPS6KB2 is primarily localized to the endoplasmic reticulum (ER) and is involved in the process of translation of mRNAs into proteins. It plays a critical role in the regulation of gene expression by targetting specific mRNAs for degradation and by regulating the translation efficiency of mRNAs. RPS6KB2 has been shown to interact with various protein partners, including poly(ADP-ribose) polymerase (PARP), which is a key regulator of DNA repair.

Drug targeting

RPS6KB2 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. One of the main advantages of RPS6KB2 as a drug target is its stability and its expression in various cell types, including cancer cells. RPS6KB2 has also been shown to be involved in the regulation of cell apoptosis, which is a critical mechanism that helps cells to eliminate damaged or dysfunctional proteins.

In addition to its potential as a drug target, RPS6KB2 has also been shown to be a potential biomarker for various diseases, including cancer. RPS6KB2 has been shown to be overexpressed in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that RPS6KB2 may be a useful biomarker for the diagnosis and prognosis of these diseases.

Anti-cancer effects

RPS6KB2 has been shown to have anti-cancer effects by inhibiting its activity. One of the mechanisms by which RPS6KB2 inhibits cancer cell growth is by inhibiting the translation of mRNAs into proteins, which is a critical step in the regulation of cell growth and division. RPS6KB2 has also been shown to inhibit the activity of PARP, which is a key regulator of DNA repair and has been shown to play a role in the regulation of cell apoptosis.

Another mechanism by which RPS6KB2 may have anti-cancer effects is by regulating the expression of genes involved in cell growth and survival. RPS6KB2 has been shown to interact with genes involved in cell cycle progression, cell apoptosis, and cell migration, which are all critical processes that are involved in the regulation of cancer cell growth and survival.

Combination therapy

Combination therapy using RPS6KB2 as a drug target and a biomarker may be an effective approach for treating cancer and other diseases. By targeting RPS6KB2, researchers may be able to inhibit its

Protein Name: Ribosomal Protein S6 Kinase B2

Functions: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193)

More Common Targets