MTMR9: A Protein Targeted in Cancer and Other Diseases (G66036)

Target Name: MTMR9

NCBI ID: G66036

MTMR9: A Protein Targeted in Cancer and Other Diseases

MTMR9 (C8orf9) is a protein that is expressed in various tissues throughout the body. It is a member of the C8 family of proteins, which are known as the carcinoembryonic antigens (CEA) family. This protein is of particular interest because it has been shown to play a role in the development and progression of many diseases, including cancer. As a result, MTMR9 has become a focus of research in the medical field, with potential as a drug target or biomarker.

One of the key functions of MTMR9 is its role in the development of cancer. MTMR9 is a transcription factor that has been shown to promote the development of many types of cancer, including breast, ovarian, and prostate cancer. This is done through its ability to induce cell proliferation and survival, as well as its role in the formation of blood vessels that feed the tumor.

In addition to its role in cancer development, MTMR9 has also been shown to contribute to the progression of many other diseases. For example, it has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Additionally, MTMR9 has been linked to a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis.

As a result of its involvement in so many different diseases, MTMR9 has become a potential drug target or biomarker. Researchers are actively searching for ways to target MTMR9 and prevent its development in cancer and other diseases. One approach that is being explored is the use of small molecules, such as drugs that can inhibit the activity of MTMR9, to treat diseases associated with MTMR9.

Another approach that is being explored is the use of antibodies that can target MTMR9. These antibodies would be designed to selectively bind to the protein and either block its activity or tag it for degradation. This would allow researchers to study the behavior of MTMR9 in live cells and determine its effectiveness as a drug or biomarker.

In addition to its potential as a drug or biomarker, MTMR9 is also of interest to researchers because of its structure and biology. The C8 family of proteins is known for its unique structure, which includes a central transmembrane domain and a series of cytoplasmic domains. This structure allows MTMR9 to interact with other proteins and molecules in the cell, and suggests that it may play a role in a wide range of cellular processes.

Overall, MTMR9 is a protein that has captured the attention of researchers due to its role in the development and progression of many diseases. As a potential drug target or biomarker, MTMR9 is an exciting area of 鈥嬧?媟esearch that has the potential to lead to new treatments for a wide range of conditions.

Protein Name: Myotubularin Related Protein 9

Functions: Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970)

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