Target Name: MTTP
NCBI ID: G4547
Other Name(s): MTTP variant 1 | MTP_HUMAN | microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit (isoform 1) | Microsomal triglyceride transfer protein (MTTP) | ABL | MTP | Microsomal triglyceride transfer protein (large polypeptide, 88kDa) | microsomal triglyceride transfer protein (large polypeptide, 88kDa) | Microsomal triglyceride transfer protein, transcript variant 1 | Microsomal triglyceride transfer protein large subunit

MTTP: A Protein Involved in Brain Metabolism and Neurological Disorders

Metformin, a drug used to treat type 2 diabetes, is one of the most commonly prescribed drugs worldwide. It works by inhibiting the function of the enzyme glucose-6-phosphate phosphatase, which is an important enzyme involved in the metabolism of glucose. Metformin is an oral anti-diabetic drug that can also be used to treat polycystic ovary syndrome (PCOS) and non-alcoholic steatohepatitis (NASH).

MTTP (MTTP variant 1) is a protein that is expressed in the brain and is involved in the metabolism of multiple nutrients, including glucose. It is a key regulator of the brain's energy metabolism and is also involved in the development and progression of neurological disorders.

MTTP variants

MTTP has four known variants, which are named after the letter combination that represents each variant. The most common variant is MTTP-derived, which is a 21-kDa protein that is expressed in the brain and is involved in the metabolism of glucose and other nutrients. The second most common variant is MTTP-related, which is a 16-kDa protein that is also expressed in the brain and is involved in the metabolism of glucose and other nutrients. The third variant is MTTP-like, which is a 12-kDa protein that is also expressed in the brain and is involved in the metabolism of glucose and other nutrients. The fourth variant is MTTP-related, which is a 16-kDa protein that is also expressed in the brain and is involved in the metabolism of glucose and other nutrients.

MTTP's role in the brain

MTTP is a key regulator of the brain's energy metabolism, and it is involved in the production and breakdown of the neurotransmitter acetylcholine. Acetylcholine is a critical neurotransmitter that is involved in memory, attention, and motor function. MTTP is also involved in the metabolism of glucose and other nutrients, which is essential for the brain's energy metabolism.

MTTP's role in neurological disorders

MTTP is also involved in the development and progression of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by the progressive loss of brain cells and the accumulation of neurotransmitters, including acetylcholine.

MTTP's potential as a drug target

MTTP's role in the brain and its involvement in the development and progression of neurological disorders make it an attractive drug target. Researchers are currently studying the potential benefits and risks of targeting MTTP with drugs.

One approach to targeting MTTP is to use drugs that can inhibit the activity of MTTP. These drugs can be used to treat neurological disorders and also have the potential to prevent the development of these disorders. For example, a drug that can inhibit the activity of MTTP could be used to treat Alzheimer's disease and other neurological disorders.

Another approach to targeting MTTP is to use drugs that can modulate the expression of MTTP. These drugs can be used to increase the amount of MTTP and to reduce its levels. For example, a drug that can increase the expression of MTTP could be used to treat Alzheimer's disease and other neurological disorders.

Conclusion

MTTP is a protein that is involved in the metabolism of multiple nutrients, including glucose, and is expressed in the brain. It is a key regulator of the brain's energy metabolism and is also involved in the development and progression of neurological disorders. As a drug target, MTTP has the potential to treat a wide range of neurological disorders, including Alzheimer's disease and other disorders that are characterized by the progressive loss of brain cells. Further research is needed to fully understand the role of MTTP

Protein Name: Microsomal Triglyceride Transfer Protein

Functions: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406, PubMed:16478722, PubMed:15897609, PubMed:8876250). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:8876250, PubMed:16478722). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity)

More Common Targets

MTURN | MTUS1 | MTUS1-DT | MTUS2 | MTUS2-AS1 | MTVR2 | MTX1 | MTX2 | MTX3 | mu-Calpain (calpain 1) | MUC1 | MUC12 | MUC13 | MUC15 | MUC16 | MUC17 | MUC19 | MUC2 | MUC20 | MUC20P1 | MUC21 | MUC22 | MUC3A | MUC3B | MUC4 | MUC5AC | MUC5B | MUC6 | MUC7 | MUC8 | Mucin | MUCL1 | MUCL3 | MUL1 | Multisubunit histone acetyltransferase complex | MUPP | MUS81 | Muscarinic Acetylcholine Receptor (mAChR) | MUSK | MUSTN1 | MUTYH | MVB12A | MVB12B | MVD | MVK | MVP | MX1 | MX2 | MXD1 | MXD3 | MXD4 | MXI1 | MXRA5 | MXRA5Y | MXRA7 | MXRA8 | MYADM | MYADML | MYADML2 | MYB | MYBBP1A | MYBL1 | MYBL2 | MYBPC1 | MYBPC2 | MYBPC3 | MYBPH | MYBPHL | MYC | MYCBP | MYCBP2 | MYCBP2-AS1 | MYCBPAP | MYCL | MYCL-AS1 | MYCLP1 | MYCN | MYCNOS | MYCNUT | MYCT1 | MYD88 | MYDGF | MYEF2 | Myelin Protein | MYEOV | MYF5 | MYF6 | MYG1 | MYH1 | MYH10 | MYH11 | MYH13 | MYH14 | MYH15 | MYH16 | MYH2 | MYH3 | MYH4 | MYH6 | MYH7