Target Name: ZNF148
NCBI ID: G7707
Other Name(s): ZNF148 variant 1 | Zinc finger DNA-binding protein 89 | Zinc finger protein 148 | Zinc finger protein 148 (isoform a) | GDACCF | Transcription factor ZBP-89 | ZN148_HUMAN | CACCC box-binding protein | HT-BETA | zinc finger DNA-binding protein 89 | zinc finger protein 148 | pHZ-52 | Zinc finger protein 148, transcript variant 2 | BERF-1 | BFCOL1 | ZNF148 variant 2 | ZBP-89 | CLL-associated antigen KW-10 | transcription factor ZBP-89 | ZFP148 | Zinc finger protein 148, transcript variant 1

ZNF148: A Potential Drug Target for Various Diseases

ZNF148 (ZNF148 variant 1) is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. ZNF148 is a non-coding RNA molecule that is composed of 148 amino acids. It is located on chromosome 6p21.3 and has been shown to play a role in the development and progression of various diseases.

One of the most significant functions of ZNF148 is its role in cell signaling. ZNF148 is a key regulator of the TGF-β pathway, which is a well-established regulator of cell growth, differentiation, and survival. The TGF-β pathway is involved in the development and maintenance of tissues and organs, and is a target for many diseases, including cancer.

ZNF148 has been shown to play a role in the regulation of TGF-β signaling in various tissues and organs. For example, studies have shown that ZNF148 is highly expressed in various tissues, including cancer tissues, and that it plays a role in the regulation of TGF-β signaling in these tissues. Additionally, overexpression of ZNF148 has been shown to promote the growth and survival of cancer cells, suggesting that it may be a useful target for cancer therapy.

Another function of ZNF148 is its role in neurodegenerative diseases. neurodegenerative diseases are a group of disorders that are characterized by the progressive loss of neural cells and their associated proteins. Many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are caused by the buildup of beta-amyloid plaques and other cellular aggregates in the brain. ZNF148 has been shown to play a role in the regulation of beta-amyloid formation and its interactions with other proteins, including the neurotransmitter dopamine.

In addition to its role in cell signaling, ZNF148 has also been shown to be involved in the regulation of immune responses. ZNF148 is a key regulator of the NF-kappa-B signaling pathway, which is involved in the regulation of immune responses. The NF-kappa-B signaling pathway is a critical regulator of inflammation, immune responses, and other physiological processes. ZNF148 has been shown to play a role in the regulation of NF-kappa-B signaling in various tissues and organs, including the immune system.

Given its various functions, ZNF148 is a promising target for drug development in a variety of diseases. For example, ZNF148 has been shown to be a potential therapeutic target for cancer, neurodegenerative diseases, and autoimmune disorders. Studies have shown that inhibiting ZNF148 activity can lead to the regression of cancer tumors, improve neurodegenerative disease symptoms, and alleviate autoimmune disorders.

In conclusion, ZNF148 is a non-coding RNA molecule that has been shown to play a critical role in a variety of diseases. Its functions include cell signaling, neurodegenerative diseases, and immune responses. Given its potential as a drug target, ZNF148 is an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of ZNF148 in disease and to develop effective therapies based on its properties.

Protein Name: Zinc Finger Protein 148

Functions: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

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