SLC39A7: A Potential Drug Target and Biomarker for Chronic Pain

Target Name: SLC39A7

NCBI ID: G7922

SLC39A7: A Potential Drug Target and Biomarker for Chronic Pain

Introduction

Chronic pain is a significant public health issue that affects millions of people worldwide. The chronic nature of pain can lead to significant disability and decreased quality of life. The gold standard for treating chronic pain is to manage symptoms effectively and to prevent new episodes of pain . However, current pain management strategies are limited in their ability to completely alleviate pain and may have potential side effects. Therefore, there is a need for new and innovative treatments that can effectively manage chronic pain without compromising patient safety.

SLC39A7: A Membrane Protein Ke4

Sodium channels, also known as sodium-calcium exchanger, are essential for many physiological processes in the body, including muscle and nerve function. SLC39A7 is a sodium channel that is expressed in various tissues, including brain, heart, and kidney. It is a member of the subfamily of the SLC gene family, which includes other well-known proteins such as SLC12A3 and SLC16A2. SLC39A7 has been shown to play a significant role in the regulation of neural excitability and pain perception.

Ke4, also known as histidine-rich membrane protein Ke4, is a unique feature of SLC39A7. It is a 120-kDa protein that is composed of a transmembrane region and a cytoplasmic region. The transmembrane region contains four intracellular loops, each of which is composed of a unique arrangement of amino acids. The cytoplasmic region contains a unique N-terminal region that is rich in histidine, which is known for its role in neurotransmitter signaling.

SLC39A7 and Pain Perception

SLC39A7 has been shown to be involved in pain perception and neurotransmission. SLC39A7 is a critical regulator of pain transmission, as it is involved in the regulation of neurotransmitter release from pain-perceiving neurons. SLC39A7 has been shown to interact with several neurotransmitters, including nitric oxide, serotonin, and dopamine. These neurotransmitters are involved in the regulation of pain perception, neurotransmission, and neuroplasticity.

In addition, SLC39A7 is involved in the regulation of pain modulation, which is critical for the maintenance of pain tolerance. SLC39A7 has been shown to interact with GABA, an inhibitory neurotransmitter that is involved in pain modulation. GABA inhibition is a critical mechanism that allows pain to be perceived as a threat and allows the body to respond to pain in an adaptive manner.

SLC39A7 and Neurotransmission

SLC39A7 is involved in the regulation of neurotransmission, which is the process by which neurons communicate with each other and with the Central nervous system. SLC39A7 is a critical regulator of neurotransmission, as it is involved in the regulation of neurotransmitter release from pain-perceiving neurons. SLC39A7 has been shown to interact with several neurotransmitters, including nitric oxide, serotonin, and dopamine. These neurotransmitters are involved in the regulation of pain perception, neurotransmission, and neuroplasticity.

In addition, SLC39A7 is involved in the regulation of pain modulation, which is critical for the maintenance of pain tolerance. SLC39A7 has been shown to interact with GABA, an inhibitory neurotransmitter that is involved in pain modulation. GABA inhibition is a critical mechanism that allows pain to be perceived as a threat and allows the body to respond to pain in an adaptive manner

Protein Name: Solute Carrier Family 39 Member 7

Functions: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:29980658, PubMed:28205653). Acts as gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:29980658, PubMed:22317921, PubMed:28205653). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in differents biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508)

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