CEP44: A Key Protein in Cell Division and The Cell Cycle (G80817)

Target Name: CEP44

NCBI ID: G80817

CEP44: A Key Protein in Cell Division and The Cell Cycle

Centrosomal protein of 44 kDa (ISOform A), also known as CEP44, is a protein that is found in the centrosome, which is a structure that forms inside the nucleus of a cell. The centrosome plays a crucial role in the cell's division process, and it is one of the most well-conserved proteins in the cell.

CEP44 is a protein that consists of 44 amino acid residues and has a calculated molecular mass of 44 kDa. It is one of the three major centrosomal proteins, along with CEP152 and CEP155, which are both involved in the formation of the centrosome.

CEP44 is a key component of the centrosome and is involved in the formation of the microtubules that organize the centrosome in the nucleus. The microtubules are made up of protein filaments that are organized in a repeating pattern to form a network that pulls the chromosomes during cell division.

CEP44 is a glycoprotein, which means that it consists of a protein that is covalently bound to a glycine molecule. This is important for its function because it allows CEP44 to interact with other proteins that are part of the centrosome.

One of the unique features of CEP44 is its role in the regulation of cell division. During cell division, the centrosome plays a crucial role in the proper alignment of the chromosomes, which is essential for accurate inheritance of genetic information.

CEP44 is also involved in the regulation of the cell cycle. It helps to control the entry of new DNA into the cell cycle and also helps to regulate the exit of chromatin into the cytoplasm. This is important for the cell's ability to divide and for the regulation of the cell cycle.

In addition to its role in cell division and the cell cycle, CEP44 is also involved in the regulation of the immune response. It has been shown to play a key role in the regulation of T cell development and activation.

CEP44 is also a potential drug target in cancer. Studies have shown that inhibiting CEP44 can lead to the regression of cancer cells. This is because CEP44 is involved in the regulation of cell growth and division, which are critical processes for the growth and survival of cancer cells.

In conclusion, CEP44 is a protein that is involved in the formation of the centrosome and is critical for the regulation of cell division, the cell cycle, and the immune response. It is also a potential drug target in cancer and has been shown to have therapeutic effects in cancer regression. Further research is needed to fully understand the role of CEP44 in the cell and its potential as a drug.

Protein Name: Centrosomal Protein 44

Functions: Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111)

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