KRTAP4-6: A Potential Drug Target and Biomarker (G81871)

Target Name: KRTAP4-6

NCBI ID: G81871

KRTAP4-6: A Potential Drug Target and Biomarker

Keratin associated protein 4-15 (KRTAP4-6) is a protein that is expressed in a variety of tissues, including hair, nails, and skin. It is a member of the keratin gene family, which encodes the proteins that make up the fundamental structure of hair and nails. KRTAP4-6 has been shown to play a role in the regulation of cell growth and differentiation, and it is potential drug target and biomarker.

The hair and nail growth cycle is a complex process that involves the regulation of many different proteins. KRTAP4-6 is one of the proteins that is involved in this regulation. During the growth cycle, KRTAP4-6 is expressed in the stem cells of the hair and nail follicles, and it plays a role in the development and differentiation of these cells into the hair and nail tips.

In addition to its role in hair and nail growth, KRTAP4-6 has also been shown to be involved in the regulation of cell survival and apoptosis. Studies have shown that KRTAP4-6 can induce cell apoptosis in response to various stressors, such as UV radiation and exposure to chemicals. This suggests that KRTAP4-6 may be a potential drug target for diseases that are characterized by cell dysfunction or death.

Another potential application of KRTAP4-6 as a drug target is its role in the development of cancer. Studies have shown that KRTAP4-6 is often overexpressed in various types of cancer, and that this overexpression is associated with poor prognosis. Additionally, KRTAP4-6 has been shown to promote the growth of cancer cells in cell culture, which suggests that it may be a useful biomarker for the evaluation of cancer therapeutic effectiveness.

In addition to its potential as a drug target and biomarker, KRTAP4-6 is also of interest as a potential biomarker for the diagnosis of certain diseases. For example, KRTAP4-6 has been shown to be expressed in the skin tissue of individuals with melanoma, a type of skin cancer. This suggests that KRTAP4-6 may be a useful biomarker for the diagnosis of melanoma.

In conclusion, KRTAP4-6 is a protein that is expressed in a variety of tissues and is involved in the regulation of cell growth and differentiation. Its potential as a drug target and biomarker makes it an attractive target for further research and development. Further studies are needed to fully understand the role of KRTAP4-6 in these processes and its potential as a drug and biomarker.

Protein Name: Keratin Associated Protein 4-6

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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