KRTAP6-2: A Potential Drug Target and Biomarker (G337967)

Target Name: KRTAP6-2

NCBI ID: G337967

Other Name(s): Keratin-associated protein 6-2 | keratin associated protein 6-2 | KAP6.2 | Keratin associated protein 6-2 | KRA62_HUMAN

KRTAP6-2: A Potential Drug Target and Biomarker

Keratin-associated protein 6-2 (KRTAP6-2) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to study, leading to a growing body of research that has shed light on its role in various biological processes.

The protein KRTAP6-2 is a member of the Keratin family, which is known for their role in the development and maintenance of hair and nails. It is composed of 254 amino acid residues and has a calculated molecular weight of 30.1 kDa. KRTAP6-2 is expressed in a variety of tissues, including skin, hair, nails, and various organs, and has been shown to play a role in various biological processes, including cell growth, differentiation, and inflammation.

One of the key features of KRTAP6-2 is its ability to interact with other proteins. It has been shown to form a complex with the protein tyrosine kinase TPK2, which is known to play a role in cell signaling and metabolism. This interaction between KRTAP6-2 and TPK2 has led to the hypothesis that KRTAP6-2 may be a drug target for TPK2-mediated diseases.

In addition to its role in cell signaling, KRTAP6-2 has also been shown to be involved in the regulation of cell adhesion. It has been shown to interact with the protein cadherin, which is a transmembrane protein that plays a role in cell-cell adhesion. This interaction between KRTAP6-2 and cadherin has led to the hypothesis that KRTAP6-2 may be a drug target for diseases characterized by disrupted cell adhesion, such as cancer.

The role of KRTAP6-2 in cancer is an area of active research, with a growing body of studies investigating its potential as a biomarker and drug target. Studies have shown that KRTAP6-2 is expressed in various types of cancer, including breast, ovarian, and prostate cancer. Additionally, research has suggested that KRTAP6-2 may be involved in the development and progression of cancer by promoting cell survival and inhibiting cell death.

In addition to its potential as a drug target, KRTAP6-2 has also been shown to be a potential biomarker for cancer. Its expression has been shown to be associated with the development and progression of various types of cancer, including breast, ovarian, and prostate cancer. Additionally, research has suggested that KRTAP6-2 may be a potential biomarker for cancer by its ability to be detected and quantified in various types of cancer.

The potential drug target for KRTAP6-2 is an area of active research, with a growing body of studies investigating its potential as a therapeutic agent. Studies have shown that KRTAP6-2 can be targeted with small molecules, antibodies, and other therapeutic agents. For example, researchers have shown that inhibition of KRTAP6-2 with small molecules can inhibit the growth and migration of cancer cells. Additionally, researchers have used antibodies to target KRTAP6-2 and block its function in cell signaling.

In conclusion, KRTAP6-2 is a protein that has shown potential as a drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to study, leading to a growing body of research that has shed light on its role in various biological processes. Further studies are needed to fully understand the potential of KRTAP6-2 as a drug

Protein Name: Keratin Associated Protein 6-2

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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