PHF5A: A Potential Drug Target (G84844)

Target Name: PHF5A

NCBI ID: G84844

PHF5A: A Potential Drug Target

PHF5A, also known as PHP50, is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the PHF family of proteins, which are characterized by the presence of a finger-like domain in their extracellular domain.

PHF5A is a 166 amino acid protein that is expressed in the brain, heart, and kidneys. It is highly conserved, with sequence similarities found in a range of organisms, including humans.PHF5A is a protein that is involved in a number of cellular processes, including cell signaling, migration, and adhesion.

One of the unique features of PHF5A is its finger-like domain, which is composed of the amino acids Asp221, Asp222, Asp223, Asp224, and Asp225. This domain is thought to be involved in the protein's stability and functions as a signaling molecule.

PHF5A has been shown to play a role in a number of physiological processes in the body, including the regulation of pain, inflammation, and cellular signaling. For example, studies have shown that PHF5A is involved in the regulation of pain perception and that it may play a role in the development of certain neurological conditions, such as multiple sclerosis.

In addition to its potential role in pain and neurological conditions, PHF5A is also being studied as a potential drug target. Several studies have shown that PHF5A is a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the reasons for the potential for PHF5A as a drug target is its conserved nature, as suggested by the high sequence similarity observed in various organisms. This conservation suggests that PHF5A may be a useful target for drugs that are effective against related proteins, which could reduce the risk of drug resistance.

Another potential mechanism by which PHF5A may be targeted by drugs is its role in cell signaling. Many drugs that are used to treat various diseases work by modulating cell signaling pathways, and PHF5A is thought to be involved in a number of these pathways. This suggests that drugs that are effective against PHF5A may be effective against a range of diseases.

In conclusion, PHF5A is a protein that is expressed in various tissues throughout the body and is involved in a number of cellular processes, including cell signaling and adhesion. Its finger-like domain and conserved nature make it a potential drug target for a variety of diseases. Further research is needed to fully understand the role of PHF5A in cellular processes and its potential as a drug target.

Protein Name: PHD Finger Protein 5A

Functions: Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643, PubMed:28541300). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

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