PI15 (PI15_HUMAN), A Potential Drug Target and Biomarker (G51050)

Target Name: PI15

NCBI ID: G51050

PI15 (PI15_HUMAN), A Potential Drug Target and Biomarker

Introduction

PI15 (phosphoryltransferase 15) is a protein that plays a crucial role in cellular signaling pathways, particularly in the regulation of cell adhesion, migration, and invasion. PI15 is a member of the PI15 family, which includes several related enzymes involved in protein synthesis and degradation. PI15 has been identified as a potential drug target and biomarker due to its unique function and its potential to modulate cellular behaviors.

Structure and Function

PI15 is a 25kDa protein that consists of two distinct domains: an N-terminal transmembrane domain and a C-terminal cytoplasmic domain. The N-terminal domain is responsible for PI15's cytoplasmic localization, while the C-terminal domain is involved in the formation of a protein-protein interaction complex with other cellular components.

PI15's unique function comes from its ability to transfer phosphate groups from its own ATP-rich loop region to other protein targets. This process is known as phosphorylation and is a well-known mechanism involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. PI15's ability to transfer phosphate groups makes it a valuable drug target and a potential biomarker.

Drug Target Potential

PI15's unique function as a protein-protein interaction target makes it an attractive drug target. The development of inhibitors that can specifically target PI15 has the potential to modulate cellular behaviors and lead to therapeutic applications. For example, by inhibiting PI15's phosphorylation activity, researchers can prevent cell adhesion, migration, and invasion, which may be useful in the treatment of various diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, PI15 has also been identified as a potential biomarker. The PI15 gene has been shown to be expressed in various human tissues and has been used as a biomarker for various diseases, including cancer. By detecting the expression and activity of PI15, researchers can monitor disease progression and evaluate the effectiveness of potential therapeutic interventions.

Biomarker Potential

PI15 has been used as a biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that PI15 is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This overexpression has been associated with poor prognosis and decreased therapeutic response.

In addition to its use as a biomarker, PI15 has also been identified as a potential therapeutic intervention in various diseases. For example, studies have shown that inhibiting PI15's phosphorylation activity can lead to the regression of cancerous tumors in both animal models and human clinical trials . This suggests that PI15 may be an effective target for cancer treatment.

Conclusion

PI15 is a unique protein with its ability to transfer phosphate groups from its own ATP-rich loop region to other protein targets. Its function as a protein-protein interaction target makes it an attractive drug target, and its potential as a biomarker has led to its identification as a potential therapeutic intervention in various diseases. Further research is needed to fully understand PI15's role in cellular signaling pathways and its potential as a drug target and biomarker.

Protein Name: Peptidase Inhibitor 15

Functions: Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity)

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