PIN1P1: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Target Name: PIN1P1

NCBI ID: G5301

Other Name(s): Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1 | PIN1L | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1

PIN1P1: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Proteasome-mediated diseases are a group of conditions characterized by the misfolding and subsequent processing of proteins into harmful forms. These diseases, including neurodegenerative disorders, cancer, and systemic autoimmune diseases, have a significant impact on human health and wellbeing. The discovery of biomarkers and potential drug targets can provide new avenues for the development of effective therapies. PIN1P1, a pseudogene located in the genomic region encoding the protein of the same name, has been identified as a potential drug target and biomarker for proteasome-mediated diseases.

PIN1P1: Structure and Function

PIN1P1 is a 21-kDa protein that is expressed in various tissues and cells, including brain, muscle, and peripheral blood cells. It is a member of the NIMA (Nucleotide-Induced MicroArray) interacting protein family, which includes several similar proteins that share a common catalytic core and distinct N-terminus regions. PIN1P1 functions as a nucleotide-binding protein that modulates the activity of nucleotide-activated protein kinases (NAPKs), which are involved in the regulation of cellular processes such as cell growth, differentiation, and stress response.

PIN1P1 has been shown to play a critical role in the regulation of several cellular processes, including cell survival, proliferation, and stress response. It has been shown to interact with several protein partners, including the transcription factor p21 (E2F1), the DNA-binding protein p53, and the ubiquitin-proteasome system (UPS).

PIN1P1 as a Drug Target

PIN1P1 has been identified as a potential drug target due to its involvement in several cellular processes that are implicated in the development of various diseases. Several studies have shown that PIN1P1 is involved in the regulation of cellular processes that are altered in several diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

For example, several studies have shown that PIN1P1 is involved in the regulation of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These studies have shown that alterations in PIN1P1 expression levels or function can contribute to the development of these disorders.

In addition to its involvement in neurodegenerative disorders, PIN1P1 has also been shown to be involved in the regulation of cancer progression. Several studies have shown that PIN1P1 is involved in the regulation of cell cycle progression, and that alterations in PIN1P1 expression levels can contribute to the development of cancer.

PIN1P1 has also been shown to be involved in the regulation of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. These studies have shown that PIN1P1 is involved in the regulation of T cell function, and that alterations in PIN1P1 expression levels can contribute to the development of these autoimmune diseases.

PIN1P1 as a Biomarker

PIN1P1 has also been shown to be a potential biomarker for several diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. The levels of PIN1P1 have been shown to be altered in several diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and cancer. These studies have shown that PIN1P1 may serve as a potential biomarker for these diseases.

In addition to its potential as a drug target, PIN1P1 has also been shown to be a potential biomarker for several diseases. The levels of PIN1P1 have

Protein Name: Peptidylprolyl Cis/trans Isomerase, NIMA-interacting 1 Pseudogene 1

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