Phosphatidylinositol Transfer Protein (PITPNM1) as A Potential Drug Target and Biomarker

Target Name: PITPNM1

NCBI ID: G9600

Phosphatidylinositol Transfer Protein (PITPNM1) as A Potential Drug Target and Biomarker

Phosphatidylinositol transfer protein (PITPNM1) is a protein that is expressed in various cell types, including neurons, endothelial cells, and cancer cells. It is a member of the phospholipid transfer protein family, which includes proteins that transport phospholipids across cell membranes.

PITPNM1 is a protein that is characterized by its ability to transfer phospholipids across cell membranes. It does this by using a unique lipid-binding domain that is located at the C-terminus of the protein. This domain is composed of a transmembrane region that contains a putative transmembranespanning segment (TMS) and a cytoplasmic region that is involved in the interaction with phospholipids.

One of the unique features of PITPNM1 is its ability to interact with various types of phospholipids, including inositol, phosphatidylcholine, and phosphatidylserine. This ability makes PITPNM1 an important protein that is involved in the regulation of various cellular processes, including cell signaling, cell division, and cell survival.

In addition to its role in the regulation of cellular processes, PITPNM1 is also a potential drug target. Several studies have suggested that PITPNM1 may be a useful target for drug development due to its unique lipid-binding domain and its involvement in various cellular processes.

One potential mechanism by which PITPNM1 may be targeted by drugs is its role in the regulation of cell signaling. PITPNM1 has been shown to play a role in the regulation of various signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular processes such as cell growth, differentiation, and survival, and is a potential target for the development of anti-cancer drugs.

Another potential mechanism by which PITPNM1 may be targeted by drugs is its role in the regulation of cell division. PITPNM1 has been shown to play a role in the regulation of cell division, including the G1/S transition and the G0/G1 transition. This suggests that PITPNM1 may be a potential target for drugs that are designed to inhibit cell division.

In addition to its potential role as a drug target, PITPNM1 is also a potential biomarker. Several studies have shown that PITPNM1 is expressed in various types of cancer cells, including breast cancer, and may be a useful biomarker for the diagnosis and prognosis of these types of cancer.

Overall, PITPNM1 is a protein that is involved in the regulation of various cellular processes and has the potential to be a drug target or biomarker. Further research is needed to fully understand the role of PITPNM1 in cellular processes and its potential as a drug target or biomarker.

Protein Name: Phosphatidylinositol Transfer Protein Membrane Associated 1

Functions: Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:22822086, PubMed:10531358). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914)

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