PLA2R1: A Potential Drug Target and Biomarker (G22925)

Target Name: PLA2R1

NCBI ID: G22925

PLA2R1: A Potential Drug Target and Biomarker

PLA2R1 (Phospholipase A2 receptor 1, 180kDa) is a protein that is expressed in various cell types, including neurons, endothelial cells, and epithelial cells. It is a member of the A2 adhesion molecule family and is involved in cell-cell adhesion, as well as in the regulation of inflammation and immune responses.

PLA2R1 has been identified as a potential drug target due to its unique structure and its involvement in several important cellular processes. One of its most significant functions is its role in cell-cell adhesion, which is critical for the development and maintenance of tissues and organs. PLA2R1 has been shown to regulate the migration and differentiation of various cell types, including neurons and endothelial cells.

In addition to its role in cell-cell adhesion, PLA2R1 is also involved in the regulation of inflammation and immune responses. It has been shown to play a key role in the regulation of T cell responses, as well as in the modulation of pain perception.

PLA2R1 is also a good candidate as a biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its expression has been shown to be elevated in various types of cancer, including breast, ovarian, and prostate cancer. It is also been shown to be involved in the progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

PLA2R1 has also been shown to be involved in the regulation of pain perception. It has been shown to play a key role in the modulation of pain sensitivity, as well as in the regulation of pain modulation.

In conclusion, PLA2R1 is a protein that has a significant impact on various cellular processes, including cell-cell adhesion, inflammation, and immune responses. Its unique structure and its involvement in several important processes make it an attractive target for drug development. Further research is needed to fully understand the role of PLA2R1 in various cellular processes and its potential as a drug or biomarker.

Protein Name: Phospholipase A2 Receptor 1

Functions: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B (PubMed:15611272, PubMed:7721806). In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis (PubMed:25335547)

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