Target Name: PLCE1
NCBI ID: G51196
Other Name(s): phosphoinositide-specific phospholipase C epsilon-1 | PLCE | Phosphoinositide-specific phospholipase C epsilon-1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Phospholipase C epsilon 1, transcript variant 1 | Phospholipase C epsilon 1 | Phosphoinositide phospholipase C-epsilon-1 | PLCE1 variant 2 | Pancreas-enriched phospholipase C | KIAA1516 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (isoform 2) | PLCE1_HUMAN | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon 1 | phosphoinositide phospholipase C-epsilon-1 | NPHS3 | PLCE1 variant 1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (isoform 1) | PPLC | phospholipase C epsilon 1 | pancreas-enriched phospholipase C | PLC-epsilon-1 | Phospholipase C epsilon 1, transcript variant 2 | Phospholipase C-epsilon-1 | phosphoinositide phospholipase C | PLCE1 variant 3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (isoform 3) | Phospholipase C epsilon 1, transcript variant 3

PLCE1: A Protein Involved in Cellular Signaling Pathways and The Blood-brain Barrier

PLCE1 (Phosphoinositide-Specific Phospholipase C-epsilon-1) is a protein that is expressed in various cell types, including neurons, endothelial cells, and liver cells. It is a member of the superfamily of phospholipase C enzymes, which are involved in the breakdown of phospholipids. This protein is unique because it is specific for phosphoinositides, which are a type of phospholipid.

PLCE1 is involved in a variety of cellular processes, including the regulation of signaling pathways, cell signaling, and cellular signaling pathways. It is also involved in the development and maintenance of the blood-brain barrier, which is responsible for protecting the brain from harmful substances.

One of the functions of PLCE1 is to regulate the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

Another function of PLCE1 is to regulate the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids. PChE is an enzyme that is involved in the production of certain neurotransmitters, including dopamine and serotonin.

PLCE1 is also involved in the regulation of cellular signaling pathways. It is involved in the production of various signaling molecules, including inositol, which is a signaling molecule that is involved in cell signaling pathways. In addition, PLCE1 is involved in the regulation of the levels of calcium ions in the cell, which are involved in various cellular processes.

PLCE1 is also involved in the development and maintenance of the blood-brain barrier. The blood-brain barrier is a specialized barrier that separates the brain from the bloodstream. It helps to protect the brain from harmful substances, such as toxins, viruses, and other harmful substances. PLCE1 is involved in the regulation of the formation and maintenance of the blood-brain barrier by breaking down certain proteins that are involved in its construction.

In addition to its role in the regulation of cellular signaling pathways and the development and maintenance of the blood-brain barrier, PLCE1 is also involved in the regulation of the levels of various phospholipids in the cell. This includes the regulation of the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids.

PLCE1 is also involved in the regulation of the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

One of the unique features of PLCE1 is its specificity for phosphoinositides. While other phospholipase C enzymes, such as PChE and FIP, are involved in the breakdown of various types of phospholipids, PLCE1 is specifically involved in the breakdown of phosphoinositides. This makes it an attractive drug target for researchers who are interested in the regulation of cellular signaling pathways.

In addition to its role in the regulation of cellular signaling pathways and the development and maintenance of the blood-brain barrier, PLCE1 is also involved in the regulation of the levels of various phospholipids in the cell. This includes the regulation of the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids.

PLCE1 is also involved in the regulation of the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

One of the unique features of PLCE1 is its specificity for phosphoinositides. While other phospholipase C enzymes, such as PChE and FIP, are involved in the breakdown of various types of phospholipids, PLCE1 is specifically involved in the breakdown of phosphoinositides. This makes it an attractive drug target for researchers who are interested in the regulation of cellular signaling pathways.

In addition to its role in the regulation of cellular signaling pathways and the development and maintenance of the blood-brain barrier, PLCE1 is also involved in the regulation of the levels of various phospholipids in the cell. This includes the regulation of the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids.

PLCE1 is also involved in the regulation of the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

One of the unique features of PLCE1 is its specificity for phosphoinositides. While other phospholipase C enzymes, such as PChE and FIP, are involved in the breakdown of various types of phospholipids, PLCE1 is specifically involved in the breakdown of phosphoinositides. This makes it an attractive drug target for researchers who are interested in the regulation of cellular signaling pathways.

In addition to its role in the regulation of cellular signaling pathways and the development and maintenance of the blood-brain barrier, PLCE1 is also involved in the regulation of the levels of various phospholipids in the cell. This includes the regulation of the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids.

PLCE1 is also involved in the regulation of the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

One of the unique features of PLCE1 is its specificity for phosphoinositides. While other phospholipase C enzymes, such as PChE and FIP, are involved in the breakdown of various types of phospholipids, PLCE1 is specifically involved in the breakdown of phosphoinositides. This makes it an attractive drug target for researchers who are interested in the regulation of cellular signaling pathways.

In addition to its role in the regulation of cellular signaling pathways and the development and maintenance of the blood-brain barrier, PLCE1 is also involved in the regulation of the levels of various phospholipids in the cell. This includes the regulation of the levels of phosphatidylcholinerglesterase (PChE), which is involved in the breakdown of phospholipids.

PLCE1 is also involved in the regulation of the levels of phosphatidylinositides (PIs) in the cell. PIs are a type of phospholipid that are involved in various cellular processes, including cell signaling and the regulation of cellular signaling pathways. PLCE1 helps to regulate the levels of PIs by breaking down the PIs into more simple components.

In conclusion, PLCE1 is a unique protein that is involved in the regulation of various cellular processes, including the regulation of cellular signaling pathways, the development and maintenance of the blood-brain barrier, and the regulation of the levels of various phospholipids in the cell. Its specificity for phosphoinositides makes it an attractive drug target for researchers who are interested in the regulation of cellular signaling pathways.

Protein Name: Phospholipase C Epsilon 1

Functions: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690)

More Common Targets

PLCE1-AS2 | PLCG1 | PLCG1-AS1 | PLCG2 | PLCH1 | PLCH2 | PLCL1 | PLCL2 | PLCXD1 | PLCXD2 | PLCXD3 | PLCZ1 | PLD1 | PLD2 | PLD3 | PLD4 | PLD5 | PLD6 | PLEC | PLEK | PLEK2 | PLEKHA1 | PLEKHA2 | PLEKHA3 | PLEKHA4 | PLEKHA5 | PLEKHA6 | PLEKHA7 | PLEKHA8 | PLEKHA8P1 | PLEKHB1 | PLEKHB2 | PLEKHD1 | PLEKHF1 | PLEKHF2 | PLEKHG1 | PLEKHG2 | PLEKHG3 | PLEKHG4 | PLEKHG4B | PLEKHG5 | PLEKHG6 | PLEKHG7 | PLEKHH1 | PLEKHH2 | PLEKHH3 | PLEKHJ1 | PLEKHM1 | PLEKHM1P1 | PLEKHM2 | PLEKHM3 | PLEKHN1 | PLEKHO1 | PLEKHO2 | PLEKHS1 | PLET1 | Plexin | PLG | PLGLA | PLGLB1 | PLGLB2 | PLGRKT | PLIN1 | PLIN2 | PLIN3 | PLIN4 | PLIN5 | PLK1 | PLK2 | PLK3 | PLK4 | PLK5 | PLLP | PLN | PLOD1 | PLOD2 | PLOD3 | PLP1 | PLP2 | PLPBP | PLPP1 | PLPP2 | PLPP3 | PLPP4 | PLPP5 | PLPP6 | PLPP7 | PLPPR1 | PLPPR2 | PLPPR3 | PLPPR4 | PLPPR5 | PLPPR5-AS1 | PLRG1 | PLS1 | PLS3 | PLSCR1 | PLSCR2 | PLSCR3 | PLSCR4