Plekho2: A Protein Modulating Cell Signaling and Adhesion (G80301)

Target Name: PLEKHO2

NCBI ID: G80301

Plekho2: A Protein Modulating Cell Signaling and Adhesion

Pleckstrin homology domain containing, family Q member 1 (PLEKHO2) is a protein that plays a crucial role in various cellular processes. It is a member of the PLEKHOMER domain family, which is known for their ability to form homodomers with other proteins. PLEKHO2 is expressed in many different tissues and cells in the body, including the brain, heart, and blood vessels.

One of the key functions of PLEKHO2 is its role in cell signaling. It is involved in the regulation of various signaling pathways, including the cAMP/cGMP signaling pathway, the insulin/IGF-1 signaling pathway, and the TGF-β signaling pathway. This protein is also involved in the regulation of ion channels, which are responsible for the flow of electrical current through cells.

Another important function of PLEKHO2 is its role in cell adhesion. It is involved in the formation of tight junctions, which are a type of cell-cell adhesion structure that helps to maintain the integrity of tissues. PLEKHO2 is also involved in the regulation of cell migration, which is essential for the development and maintenance of tissues and organs.

In addition to its role in cell signaling and adhesion, PLEKHO2 is also involved in the regulation of various cellular processes that are important for the survival of cells. For example, it is involved in the regulation of cell cycle progression, which is the process by which cells grow, divide, and replicate themselves. PLEKHO2 is also involved in the regulation of apoptosis, which is the process by which cells are programmed to die.

Given its involvement in so many important cellular processes, PLEKHO2 is a potential drug target. Researchers are currently working to develop new treatments for various diseases that are caused by the disruption of PLEKHO2 signaling. For example, scientists are working to develop new treatments for heart failure, which is a condition that is characterized by the inability of the heart to pump enough blood to meet the needs of the body.

In addition to its potential as a drug target, PLEKHO2 is also a potential biomarker. Researchers are using this protein to develop new diagnostic tests for various diseases. For example, they are using PLEKHO2 to develop new tests for cancer, including breast, ovarian, and prostate cancers.

Overall, PLEKHO2 is a protein that plays a crucial role in various cellular processes in the body. It is a potential drug target and biomarker, and its research is an important area of study in the field of molecular biology. Further research is needed to fully understand the role of PLEKHO2 in cell signaling and its potential as a drug and biomarker.

Protein Name: Pleckstrin Homology Domain Containing O2

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